Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21606312 | 0.87 | TP53 (0.47) | KMT2AMEN1MAPTHDAC6ALDH1A1 | |
| SCHEMBL21606274 | 0.80 | STING1 (0.51) | KMT2AMEN1MAPTPOLB | |
| SCHEMBL21606273 | 0.79 | PARK7 (0.52) | KMT2AMEN1HPGDMAPTPARK7 | |
| SCHEMBL23769015 | 0.78 | KMT2A (0.50) | KMT2AMEN1HPGDMAPTPARK7 | |
| SCHEMBL29256261 | 0.77 | STING1 (0.50) | KMT2AMEN1HPGDMAPTPARK7 | |
| SCHEMBL23769102 | 0.77 | STING1 (0.50) | KMT2AMEN1HPGDMAPTPARK7 | |
| SCHEMBL31411806 | 0.72 | ELANE (0.55) | KMT2AMEN1HPGDMAPTELANE | |
| SCHEMBL23768992 | 0.71 | ALDH1A1 (0.71) | MAPTALDH1A1POLB | |
| SCHEMBL29978848 | 0.71 | ALDH1A1 (0.71) | MAPTALDH1A1POLB | |
| SCHEMBL20580653 | 0.70 | MEN1 (0.55) | KMT2AMEN1HPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243823-A1 | AZAHETEROCYCLIC SMALL MOLECULE MODULATORS OF HUMAN STING | CURADEV PHARMA LIMITED (GB) | 2019-12-26 | — | — | WO | disclosed |