Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21606405 | 0.89 | NOTUM (0.49) | NOTUMOPRK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21606501 | 0.83 | GABRA2 (0.40) | OPRK1L3MBTL1SMN1; SMN2GABRG2GABRB3 | |
| SCHEMBL21606455 | 0.81 | GABRA2 (0.40) | OPRK1L3MBTL1GABRG2GABRB3GABRA5 | |
| SCHEMBL21605613 | 0.75 | FAAH (0.39) | OPRK1L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21598060 | 0.74 | RORC (0.45) | OPRK1L3MBTL1ALDH1A1 | |
| SCHEMBL27592203 | 0.74 | NOTUM (0.53) | NOTUMMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL21606475 | 0.74 | RORC (0.46) | — | |
| SCHEMBL9372779 | 0.73 | NOTUM (0.61) | NOTUMMEN1KMT2AGABRA2GABRB2 | |
| SCHEMBL31309319 | 0.73 | RXFP1 (0.45) | MEN1KMT2ASMN1; SMN2GAAGABRG2 | |
| SCHEMBL21639372 | 0.72 | NOTUM (0.67) | NOTUMMEN1KMT2ASMN1; SMN2GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019244000-A1 | PHENYL AND PYRIDINYL SUBSTITUTED IMIDAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |