Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21606397 | 0.89 | NOTUM (0.47) | NOTUMOPRK1MEN1KMT2AALDH1A1 | |
| SCHEMBL21606347 | 0.79 | GABRA2 (0.42) | OPRK1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL195517 | 0.77 | PSEN1 (0.42) | — | |
| SCHEMBL27592203 | 0.76 | NOTUM (0.53) | NOTUMMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9372779 | 0.75 | NOTUM (0.61) | NOTUMMEN1KMT2A | |
| SCHEMBL9465006 | 0.75 | NOTUM (0.68) | NOTUMMEN1KMT2AGAAMAPT | |
| SCHEMBL21639372 | 0.74 | NOTUM (0.67) | NOTUMMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL21195187 | 0.73 | MEN1 (0.33) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1881082 | 0.72 | NOTUM (0.65) | NOTUMMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL21606545 | 0.71 | RORC (0.42) | OPRK1ALDH1A1GAAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019244000-A1 | PHENYL AND PYRIDINYL SUBSTITUTED IMIDAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |