Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21608114 | 0.85 | ADORA2B (0.51) | ALDH1A1GPR119KDM1AKDM4EADORA2B | |
| SCHEMBL21607889 | 0.83 | TACR1 (0.42) | ALDH1A1GPR119MGLLMAPTACKR3 | |
| SCHEMBL13985662 | 0.78 | ADORA2B (0.49) | ALDH1A1GPR119KDM1AKDM4EADORA2B | |
| SCHEMBL15205904 | 0.78 | GPR119 (0.43) | ALDH1A1GPR119MAPTHTTKDM4E | |
| SCHEMBL21608370 | 0.77 | TBK1 (0.49) | GPR119VEGFAEGLN1MEN1KMT2A | |
| SCHEMBL16486773 | 0.77 | ACKR3 (0.46) | ALDH1A1GPR119KDM1AACKR3VEGFA | |
| SCHEMBL29390664 | 0.77 | ACKR3 (0.46) | ALDH1A1GPR119KDM1AACKR3VEGFA | |
| SCHEMBL21607843 | 0.76 | TBK1 (0.56) | GPR119TBK1 | |
| SCHEMBL21608113 | 0.76 | SLC2A1 (0.45) | ALDH1A1GPR119HTT | |
| SCHEMBL892981 | 0.75 | ALDH1A1 (0.54) | ALDH1A1GPR119LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243531-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |