Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 4/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.45 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7769580 | 0.86 | PLA2G10 (0.70) | PLA2G10PSMB5CERT1MEN1FAAH | |
| SCHEMBL7769502 | 0.86 | PLA2G10 (0.70) | PLA2G10PSMB5CERT1MEN1FAAH | |
| SCHEMBL7769504 | 0.86 | PLA2G10 (0.70) | PLA2G10PSMB5CERT1MEN1FAAH | |
| SCHEMBL13002248 | 0.86 | HDAC3 (0.48) | PLA2G10CERT1MEN1FAAHMAPK1 | |
| SCHEMBL27105837 | 0.85 | PLA2G10 (0.47) | PLA2G10CERT1MMETAS1R3TAS1R1 | |
| SCHEMBL4338144 | 0.84 | MME (0.42) | PLA2G10CERT1HDAC6MMETAS1R3 | |
| SCHEMBL16351240 | 0.83 | DNM1 (0.54) | PLA2G10PSMB5MEN1FAAHMAPK1 | |
| SCHEMBL24744385 | 0.82 | PARP1 (0.45) | CERT1MEN1FAAHMAPK1KMT2A | |
| SCHEMBL10902941 | 0.80 | ALDH1A1 (0.49) | PLA2G10MMETAS1R3TAS1R1 | |
| SCHEMBL10902934 | 0.80 | ALDH1A1 (0.49) | PLA2G10MMETAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112074513-B | Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists | 豪夫迈·罗氏有限公司 | 2024-06-14 | — | — | CN | disclosed |
| EP-3814337-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PREFERENTIAL CANNABINOID 2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2021-05-05 | — | — | EP | disclosed |
| WO-2020002270-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PREFERENTIAL CANNABINOID 2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-01-02 | — | — | WO | disclosed |