Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.46 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24744385 | 0.91 | PARP1 (0.45) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL19142525 | 0.86 | DNM1 (0.56) | DNM1CERT1MEN1KMT2AFAAH | |
| SCHEMBL21609362 | 0.86 | PLA2G10 (0.51) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL29893217 | 0.85 | DNM1 (0.65) | DNM1CERT1MEN1KMT2AFAAH | |
| SCHEMBL22183458 | 0.84 | CNR2 (0.40) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL19520081 | 0.83 | HDAC3 (0.50) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL679967 | 0.83 | DNM1 (0.68) | DNM1CERT1MEN1KMT2AFAAH | |
| SCHEMBL3243330 | 0.83 | DNM1 (0.68) | DNM1CERT1MEN1KMT2AFAAH | |
| SCHEMBL23799220 | 0.83 | DNM1 (0.68) | DNM1CERT1MEN1KMT2AFAAH | |
| SCHEMBL14159281 | 0.83 | DNM1 (0.68) | DNM1CERT1MEN1KMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200277406-A1 | BINDING AGENT | ROCHE DIAGNOSTICS GMBH (DE) | 2020-09-03 | — | — | US | disclosed |
| EP-2714681-B1 | SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-06-24 | — | — | EP | disclosed |
| US-7846964-B2 | Thiophene derivatives as spingosine-1-phosphate-1 receptor agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-12-07 | — | — | US | disclosed |
| US-7846964-B2 | Thiophene derivatives as spingosine-1-phosphate-1 receptor agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-12-07 | — | — | US | disclosed |
| US-20080194670-A1 | Novel Thiophene Derivatives as Spingosine-1-Phosphate-1 Receptor Agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-08-14 | — | — | US | disclosed |
| US-20080194670-A1 | Novel Thiophene Derivatives as Spingosine-1-Phosphate-1 Receptor Agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194670-A1 | Novel Thiophene Derivatives as Spingosine-1-Phosphate-1 Receptor Agonists | GRK2, GRK4, GPR174 | HDAC3 3657/4885HDAC1 3365/4885HDAC2 4164/4885 |
| US-20200277406-A1 | BINDING AGENT | SSB, APBA1, SHBG | HDAC3 4431/4885HDAC1 2592/4885HDAC2 3823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.