SCHEMBL21609746

SCHEMBL21609746

Cc1ccnc(Oc2ncccn2)c1Sc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.33
▸ MAPT P10636 6/20 0.32
▸ SMN1; SMN2 Q16637 5/20 0.32
▸ ALDH1A1 P00352 4/20 0.32
▸ GAA P10253 3/20 0.32
▸ KMT2A Q03164 3/20 0.32
▸ MEN1 O00255 2/20 0.32
▸ L3MBTL1 Q9Y468 2/20 0.32
▸ TP53 P04637 1/20 0.32
▸ PPP1CA P62136 1/20 0.32
▸ APAF1 O14727 1/20 0.31
▸ CYP2C9 P11712 2/20 0.30
▸ CYP2C19 P33261 2/20 0.30
▸ RAB9A P51151 1/20 0.30
▸ CYP1A2 P05177 1/20 0.30
▸ CYP3A4 P08684 1/20 0.30
▸ PKM P14618 1/20 0.30
▸ KDM4E B2RXH2 1/20 0.30
▸ HSD17B10 Q99714 1/20 0.30
▸ TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20659430 0.78 LMNA (0.41) POLBMAPTSMN1; SMN2GAAKMT2A
SCHEMBL20671317 0.77 ALDH1A1 (0.36) POLBMAPTALDH1A1GAAKMT2A
SCHEMBL20671575 0.75 POLB (0.39) POLBMAPTSMN1; SMN2GAATP53
SCHEMBL22027756 0.74 POLB (0.48) POLBMAPTSMN1; SMN2GAAKMT2A
SCHEMBL20659816 0.74 POLB (0.36) POLBMAPTSMN1; SMN2ALDH1A1GAA
SCHEMBL21609744 0.70 SMN1; SMN2 (0.37) SMN1; SMN2ALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL31057923 0.70 SMN1; SMN2 (0.37) SMN1; SMN2ALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL20671368 0.69 POLB (0.43) POLBMAPTSMN1; SMN2GAATP53
SCHEMBL5887695 0.66 TSHR (0.43) POLBMAPTSMN1; SMN2ALDH1A1GAA
SCHEMBL11154875 0.66 MEN1 (0.36) MAPTSMN1; SMN2ALDH1A1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112469712-B Substituted 2-heteroaryloxy pyridines and salts thereof, and their use as herbicides 拜耳公司 2024-08-13 — — CN disclosed
US-11834434-B2 Substituted 2-heteroaryloxypyridines and salts thereof and their use as herbicidal agents BAYER AKTIENGESELLSCHAFT (DE) 2023-12-05 — — US disclosed
US-11834434-B2 Substituted 2-heteroaryloxypyridines and salts thereof and their use as herbicidal agents BAYER AKTIENGESELLSCHAFT (DE) 2023-12-05 — — US disclosed
US-11834434-B2 Substituted 2-heteroaryloxypyridines and salts thereof and their use as herbicidal agents BAYER AKTIENGESELLSCHAFT (DE) 2023-12-05 — — US disclosed
US-20210276974-A1 SUBSTITUTED 2-HETEROARYLOXYPYRIDINES AND SALTS THEREOF AND THEIR USE AS HERBICIDAL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 2021-09-09 — — US disclosed
US-20210276974-A1 SUBSTITUTED 2-HETEROARYLOXYPYRIDINES AND SALTS THEREOF AND THEIR USE AS HERBICIDAL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 2021-09-09 — — US disclosed
EP-3810589-A1 SUBSTITUTED 2-HETEROARYLOXYPYRIDINES AND SALTS THEREOF AND THEIR USE AS HERBICIDAL AGENTS Bayer Aktiengesellschaft (DE) 2021-04-28 — — EP disclosed
CN-112469712-A Substituted 2-heteroaryloxypyridines and their salts and their use as herbicides 拜耳公司 2021-03-09 — — CN disclosed
WO-2020002089-A1 SUBSTITUTED 2-HETEROARYLOXYPYRIDINES AND SALTS THEREOF AND THEIR USE AS HERBICIDAL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 2020-01-02 — — WO disclosed
WO-2020002089-A1 SUBSTITUTED 2-HETEROARYLOXYPYRIDINES AND SALTS THEREOF AND THEIR USE AS HERBICIDAL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 2020-01-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210276974-A1 SUBSTITUTED 2-HETEROARYLOXYPYRIDINES AND SALTS THEREOF AND THEIR USE AS HERBICIDAL AGENTS DDT, AGPS, GMDS POLB 3758/4885MAPT 4325/4885SMN1; SMN2 4832/4885
US-11834434-B2 Substituted 2-heteroaryloxypyridines and salts thereof and their use as herbicidal agents DDT, AGPS, GMDS POLB 3758/4885MAPT 4325/4885SMN1; SMN2 4832/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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