Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16624730 | 0.81 | SMN1; SMN2 (0.48) | TDP1NPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL16624654 | 0.77 | TDP1 (0.39) | TDP1NPC1SMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL20799451 | 0.77 | HPGD (0.46) | TDP1ALDH1A1MAPTKDM4EHTT | |
| SCHEMBL17954336 | 0.76 | HPGD (0.44) | TDP1ALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL21610292 | 0.76 | ALDH1A1 (0.49) | SMN1; SMN2L3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL22333840 | 0.73 | DHFR (0.46) | TDP1NPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL20101392 | 0.73 | TDP1 (0.36) | TDP1NPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL21610289 | 0.72 | SMN1; SMN2 (0.70) | TDP1NPC1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5808263 | 0.71 | SMN1; SMN2 (0.38) | TDP1NPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL21610291 | 0.70 | PDE10A (0.40) | NPC1SMN1; SMN2L3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10519446-B2 | Organic compounds to treat hepatitis B virus | NOVARTIS AG (CH) | 2019-12-31 | — | — | US | disclosed |