Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.39 |
| ▸ | EBP | Q15125 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21613743 | 0.86 | ALDH1A1 (0.41) | DHCR7EBPKDM4EKMT2AMEN1 | |
| SCHEMBL21613703 | 0.77 | KDM4E (0.41) | DHCR7EBPKDM4EKMT2AMEN1 | |
| SCHEMBL21613709 | 0.75 | CHRNA7 (0.40) | CHRM4KDM4E | |
| SCHEMBL21613735 | 0.75 | ACHE (0.45) | DHCR7EBPKDM4EKMT2AMEN1 | |
| SCHEMBL21613752 | 0.75 | KDM4E (0.41) | DHCR7EBPKDM4EKMT2AMEN1 | |
| SCHEMBL22080875 | 0.74 | EBP (0.48) | DHCR7EBPKDM4EKMT2AMEN1 | |
| SCHEMBL21613700 | 0.74 | HRH3 (0.43) | KMT2AMEN1CYP2D6HTTTSHR | |
| SCHEMBL26004529 | 0.74 | KDM4E (0.39) | DHCR7EBPKDM4EKMT2AMEN1 | |
| SCHEMBL21613744 | 0.73 | KDM4E (0.45) | DHCR7EBPKDM4EKMT2AMEN1 | |
| SCHEMBL21613806 | 0.72 | DHCR7 (0.50) | DHCR7EBPKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3322417-B1 | TARGETING EMOPAMIL BINDING PROTEIN (EBP) WITH SMALL MOLECULES THAT INDUCE AN ABNORMAL FEEDBACK RESPONSE BY LOWERING ENDOGENOUS CHOLESTEROL BIOSYNTHESIS | UNIV TEXAS (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-3044218-B1 | THERAPEUTICS TARGETING TRUNCATED ADENOMATOUS POLYPOSIS COLI (APC) PROTEINS | UNIV TEXAS (US) | 2020-05-27 | — | — | EP | disclosed |