Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.36 |
| ▸ | EBP | Q15125 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21613735 | 0.81 | ACHE (0.45) | KDM4EALDH1A1TSHRCYP2D6CYP2C19 | |
| SCHEMBL21613752 | 0.81 | KDM4E (0.41) | KDM4EL3MBTL1ALDH1A1L3MBTL3CYP2D6 | |
| SCHEMBL21613744 | 0.79 | KDM4E (0.45) | KDM4EL3MBTL1ALDH1A1L3MBTL3CYP2D6 | |
| SCHEMBL20627169 | 0.78 | L3MBTL1 (0.46) | KDM4EL3MBTL1ALDH1A1TSHRRECQL | |
| SCHEMBL22080875 | 0.78 | EBP (0.48) | KDM4EALDH1A1CYP2D6CYP2C19LMNA | |
| SCHEMBL21613808 | 0.77 | DHCR7 (0.39) | KDM4ETSHRCYP2D6DHCR7EBP | |
| SCHEMBL26004529 | 0.77 | KDM4E (0.39) | KDM4EL3MBTL1ALDH1A1TSHRL3MBTL3 | |
| SCHEMBL21613801 | 0.77 | RAB9A (0.41) | KDM4EL3MBTL1RECQLL3MBTL3CYP2D6 | |
| SCHEMBL20627070 | 0.75 | LMNA (0.40) | L3MBTL3CYP2D6CYP2C19LMNA | |
| SCHEMBL20627361 | 0.75 | MAOB (0.36) | CYP2D6LMNAPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020117972-A1 | THERAPEUTICS TARGETING MUTANT ADENOMATOUS POLYPOSIS COLI (APC) FOR THE TREATMENT OF CANCER | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-06-11 | — | — | WO | disclosed |
| EP-3044218-B1 | THERAPEUTICS TARGETING TRUNCATED ADENOMATOUS POLYPOSIS COLI (APC) PROTEINS | UNIV TEXAS (US) | 2020-05-27 | — | — | EP | disclosed |