Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 14/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496564 | 0.82 | KDM4E (0.55) | HCRTR1HCRTR2KDM4EPKM | |
| SCHEMBL17948786 | 0.75 | KDM4E (0.53) | PPARDKDM4EPKM | |
| SCHEMBL270496 | 0.73 | ALPL (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL269009 | 0.73 | PIN1 (0.61) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL496662 | 0.71 | KDM4E (0.72) | HCRTR1HCRTR2KDM4EPKM | |
| SCHEMBL22256926 | 0.70 | TARBP2 (0.57) | HCRTR1HCRTR2KDM4EPKM | |
| SCHEMBL268643 | 0.69 | KDM4E (0.49) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL984476 | 0.68 | KMO (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL80459 | 0.68 | ALOX5 (0.61) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL269439 | 0.67 | SMN1; SMN2 (0.48) | HCRTR1HCRTR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099511-A1 | BENZIMIDAZOLE-2-METHYL-MORPHOLINE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2020-05-22 | — | — | WO | disclosed |
| WO-2020007977-A1 | 7-TRIFLUOROMETHYL-[1,4]DIAZEPAN DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2020-01-09 | — | — | WO | disclosed |
| WO-2020007964-A1 | 2-(2-AZABICYCLO[3.1.0]HEXAN-1-YL)-1H-BENZIMIDAZOLE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2020-01-09 | — | — | WO | disclosed |