Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 7/20 | 0.37 |
| ▸ | F2R | P25116 | 4/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23631891 | 0.91 | SRD5A2 (0.39) | SRD5A2PTGER4F2RPSEN1PSEN2 | |
| SCHEMBL28533682 | 0.91 | SRD5A2 (0.39) | SRD5A2PTGER4F2RPSEN1PSEN2 | |
| SCHEMBL28540107 | 0.91 | SRD5A2 (0.39) | SRD5A2PTGER4F2RPSEN1PSEN2 | |
| SCHEMBL28910602 | 0.89 | FPR1 (0.41) | SRD5A2PTGER4F2RKDM4EALDH1A1 | |
| SCHEMBL28526814 | 0.87 | SRD5A2 (0.39) | SRD5A2PTGER4F2RKDM4EALDH1A1 | |
| SCHEMBL28910599 | 0.85 | P2RY14 (0.37) | SRD5A2PTGER4F2RKDM4EALDH1A1 | |
| SCHEMBL28542875 | 0.85 | SRD5A2 (0.37) | SRD5A2PTGER4F2RKDM4EALDH1A1 | |
| SCHEMBL28532591 | 0.84 | SRD5A2 (0.36) | SRD5A2PTGER4F2RPSEN1PSEN2 | |
| SCHEMBL28533648 | 0.84 | P2RY14 (0.43) | SRD5A2PTGER4F2RKDM4EALDH1A1 | |
| SCHEMBL28525709 | 0.84 | SRD5A2 (0.43) | SRD5A2PTGER4F2RLTA4HP2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112513021-B | ROR gamma antagonist and application thereof in medicines | 广东东阳光药业有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-112513021-A | ROR gamma antagonist and application thereof in medicine | 广东东阳光药业有限公司 | 2021-03-16 | — | — | CN | disclosed |
| WO-2020011147-A1 | RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-01-16 | — | — | WO | disclosed |