Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 9/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | DGKZ | Q13574 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23632253 | 0.91 | HSD11B1 (0.40) | KIF11ELANECYP2C9HSD11B1CYP3A4 | |
| SCHEMBL28537013 | 0.89 | ELANE (0.36) | KIF11ELANECYP2C9HSD11B1CYP3A4 | |
| SCHEMBL28532578 | 0.88 | KIF11 (0.37) | KIF11ELANECYP2C9HSD11B1CYP3A4 | |
| SCHEMBL21616650 | 0.88 | KIF11 (0.37) | KIF11HSD11B1CYP3A4HTTHRH3 | |
| SCHEMBL21616677 | 0.86 | KIF11 (0.37) | KIF11ELANECYP2C9HSD11B1CYP3A4 | |
| SCHEMBL21616587 | 0.85 | KIF11 (0.42) | KIF11ELANECYP2C9HSD11B1CYP3A4 | |
| SCHEMBL21616599 | 0.84 | KIF11 (0.41) | KIF11ELANECYP2C9HSD11B1CYP3A4 | |
| SCHEMBL28526814 | 0.83 | SRD5A2 (0.39) | — | |
| SCHEMBL23633001 | 0.83 | EPHX2 (0.43) | KIF11DGKZHRH3 | |
| SCHEMBL28535402 | 0.82 | HSD11B1 (0.38) | KIF11ELANECYP2C9HSD11B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112513021-B | ROR gamma antagonist and application thereof in medicines | 广东东阳光药业有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-112513021-A | ROR gamma antagonist and application thereof in medicine | 广东东阳光药业有限公司 | 2021-03-16 | — | — | CN | disclosed |
| WO-2020011147-A1 | RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-01-16 | — | — | WO | disclosed |