Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DGKZ | Q13574 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28535402 | 0.91 | HSD11B1 (0.38) | HSD11B1KIF11ELANECYP2C9HRH3 | |
| SCHEMBL21616640 | 0.91 | KIF11 (0.38) | HSD11B1KIF11ELANECYP2C9HRH3 | |
| SCHEMBL28537768 | 0.90 | HSD11B1 (0.38) | HSD11B1KIF11HRH3CYP3A4HTR2C | |
| SCHEMBL28535429 | 0.89 | HSD11B1 (0.37) | HSD11B1KIF11ELANECYP2C9CYP3A4 | |
| SCHEMBL30474464 | 0.87 | KDM1A (0.35) | KIF11HTR2CDGKZ | |
| SCHEMBL28540005 | 0.86 | KIF11 (0.41) | HSD11B1KIF11ELANECYP2C9HRH3 | |
| SCHEMBL21616615 | 0.85 | HSD11B1 (0.42) | HSD11B1KIF11CYP3A4HTR2CHTT | |
| SCHEMBL23632362 | 0.85 | HSD11B1 (0.42) | HSD11B1KIF11CYP3A4HTR2CHTT | |
| SCHEMBL28539964 | 0.84 | HSD11B1 (0.42) | HSD11B1KIF11ELANECYP2C9HRH3 | |
| SCHEMBL21616645 | 0.84 | P2RY14 (0.38) | P2RY14EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072542-B | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| WO-2021139595-A1 | RORγT INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 东莞市东阳光新药研发有限公司 | 2021-07-15 | — | — | WO | disclosed |
| CN-113072542-A | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |