SCHEMBL21621091

SCHEMBL21621091

Clc1cccc2ccc(Nc3cccc(Oc4ccccc4)c3)nc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 1/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
MAPT P10636 3/20 0.41
MAPK1 P28482 2/20 0.41
XPO1 O14980 2/20 0.40
SIRT2 Q8IXJ6 1/20 0.40
SIRT1 Q96EB6 1/20 0.40
POLB P06746 2/20 0.40
MITF O75030 1/20 0.40
ALDH1A1 P00352 1/20 0.40
HTT P42858 1/20 0.40
SYK P43405 1/20 0.40
DHFR P00374 1/20 0.40
CTSC P53634 1/20 0.39
SCN9A Q15858 1/20 0.39
KDM4E B2RXH2 1/20 0.39
ALPG P10696 1/20 0.39
RAB9A P51151 1/20 0.39
TDP1 Q9NUW8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30764789 1.00 KDR (0.41) KDRMEN1KMT2AMAPTMAPK1
SCHEMBL21617050 0.89 SCN9A (0.50) KDRMEN1KMT2AMAPTXPO1
SCHEMBL30603856 0.85 MEN1 (0.60) KDRMEN1KMT2AMAPTMAPK1
SCHEMBL29110571 0.85 MEN1 (0.60) KDRMEN1KMT2AMAPTMAPK1
SCHEMBL18434270 0.84 RAB9A (0.55) MEN1KMT2AMAPTMAPK1XPO1
SCHEMBL1702145 0.82 CTSC (0.51) SYKDHFRCTSC
SCHEMBL21621090 0.82 SCN9A (0.42) XPO1ALDH1A1SYKSCN9AKDM4E
SCHEMBL21617070 0.82 XPO1 (0.42) MEN1KMT2AXPO1ALDH1A1SYK
SCHEMBL30764783 0.82 XPO1 (0.42) MEN1KMT2AXPO1ALDH1A1SYK
SCHEMBL21617073 0.82 SCN9A (0.48) MEN1KMT2AMAPTMAPK1XPO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035348-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2026-02-05 US disclosed
US-12479802-B2 Phenyl-n-quinoline derivatives for treating a RNA virus infection ABIVAX (FR) 2025-11-25 US disclosed
US-20240308964-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2024-09-19 US disclosed
US-12084422-B2 Phenyl-n-quinoline derivatives for treating a RNA virus infection ABIVAX (FR) 2024-09-10 US disclosed
CN-112566899-B phenyl-N-quinoline derivatives for the treatment of RNA viral infections ABIVAX公司 2024-01-30 CN disclosed
US-20210309611-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-10-07 US disclosed
US-20210309611-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-10-07 US disclosed
CN-112566899-A phenyl-N-quinoline derivatives for the treatment of RNA viral infections ABIVAX公司 2021-03-26 CN disclosed
WO-2020011810-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240308964-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ORC3, NSUN3, POLR2H KDR 3485/4885MEN1 4277/4885KMT2A 4178/4885
US-12084422-B2 Phenyl-n-quinoline derivatives for treating a RNA virus infection ORC3, NSUN3, POLR2H KDR 3485/4885MEN1 4277/4885KMT2A 4178/4885
US-20260035348-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION SARS1, NDUFC2, CLIC1 KDR 2868/4885MEN1 3696/4885KMT2A 2282/4885
US-12479802-B2 Phenyl-n-quinoline derivatives for treating a RNA virus infection ORC3, NSUN3, POLR2H KDR 3485/4885MEN1 4277/4885KMT2A 4178/4885
US-20210309611-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ORC3, NSUN3, POLR2H KDR 3485/4885MEN1 4277/4885KMT2A 4178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.