Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 7/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL28128937 | 0.91 | CYP2A6 (0.47) | CYP2A6ALOX12CYP1A2TSHRALDH1A1 | |
| Anthracene SCHEMBL1456301 | 0.87 | CYP2A6 (0.50) | CYP2A6ALOX12CYP1A2ALDH1A1TDP1 | |
| Naphthalene SCHEMBL27339031 | 0.87 | CYP2A6 (0.50) | CYP2A6ALOX12CYP1A2TSHRTDP1 | |
| Naphthalene SCHEMBL28109289 | 0.86 | ALDH1A1 (0.43) | CYP2A6ALOX12CYP1A2TSHRALDH1A1 | |
| Naphthalene SCHEMBL28031965 | 0.86 | PSIP1 (0.42) | CYP2A6ALOX12CYP1A2TSHRALDH1A1 | |
| Naphthalene SCHEMBL11774251 | 0.85 | CYP2A6 (0.67) | CYP2A6ALOX12CYP1A2TSHRALDH1A1 | |
| Alcohol SCHEMBL14841565 | 0.84 | CYP2A6 (0.48) | CYP2A6ALOX12CYP1A2ALDH1A1TDP1 | |
| Naphthalene SCHEMBL28227167 | 0.84 | CYP2A6 (0.47) | CYP2A6ALOX12CYP1A2TSHRTDP1 | |
| Phenanthrene SCHEMBL29175455 | 0.82 | ALDH1A1 (0.67) | CYP2A6CYP1A2TSHRALDH1A1TDP1 | |
| Naphthalene SCHEMBL1080458 | 0.81 | CYP2A6 (0.61) | CYP2A6ALOX12CYP1A2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 292 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117800816-B | Green synthesis method of polysubstituted benzyl ether and polysubstituted benzaldehyde | 华东理工大学 | 2026-02-27 | — | — | CN | claimed |
| CN-120059810-A | Blending method of high-cleanliness modified methanol fuel | 全椒圣宝新能源科技有限公司 | 2025-05-30 | — | — | CN | claimed |
| CN-119504431-A | Method for esterification of carboxylic acid and continuous flow photochemistry device | 国网安徽省电力有限公司电力科学研究院 | 2025-02-25 | — | — | CN | claimed |
| CN-119504430-A | Carboxylic acid esterification method and gas-liquid mixed flow photochemical device | 国网安徽省电力有限公司电力科学研究院 | 2025-02-25 | — | — | CN | claimed |
| CN-119504433-A | Carboxylic acid esterification method | 国网安徽省电力有限公司电力科学研究院 | 2025-02-25 | — | — | CN | claimed |
| CN-118909207-B | Micron-sized polymer microsphere and preparation method and application thereof | 长园新能源材料研究院(广东)有限公司 | 2025-02-07 | — | — | CN | claimed |
| CN-119359104-A | Method for evaluating quality stability of cigarette products based on multidimensional space chemical fingerprint | 山西昆明烟草有限责任公司 | 2025-01-24 | — | — | CN | claimed |
| CN-119361001-A | Method for evaluating quality difference of cigarette products based on multidimensional space chemical fingerprint | 山西昆明烟草有限责任公司 | 2025-01-24 | — | — | CN | claimed |
| CN-118909207-A | Micron-sized polymer microsphere and preparation method and application thereof | 长园新能源材料研究院(广东)有限公司 | 2024-11-08 | — | — | CN | claimed |
| CN-118724845-A | Method for preparing ether derivatives by low-cost metal catalysis | 哈尔滨工业大学(深圳)(哈尔滨工业大学深圳科技创新研究院) | 2024-10-01 | — | — | CN | claimed |
| CN-105732520-A | Method of synthesizing quinazolinone-structured compound | 中国科学院大连化学物理研究所 | 2016-07-06 | — | — | CN | claimed |
| US-20150315227-A1 | PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF | UNIVERSITY OF COLORADO BOULDER | 2015-11-05 | — | — | US | claimed |
| WO-2015168461-A2 | PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF | AGILENT TECHNOLOGIES, INC. (US) | 2015-11-05 | — | — | WO | claimed |
| CN-101296953-A | High molecular weight poly(dially dialkyl) ammonium salts | CIBA HOLDING INC (CH) | 2008-10-29 | — | — | CN | claimed |
| CN-1236363-C | Electrophotographic photoconductors comprising polyaryl ethers | LEXMARK INT INC (US) | 2006-01-11 | — | — | CN | claimed |
| CN-1397030-A | Electrophotographic photoconductors comprising polyaryl ethers | LEXMARK INT INC (US) | 2003-02-12 | — | — | CN | claimed |
| CN-1086105-C | Plant-propagating liquid and its preparing method | QU JINGHUA (CN) | 2002-06-12 | — | — | CN | claimed |
| EP-0122151-B1 | PRODUCTION OF PRIMARY OR SECONDARY ALCOHOL DERIVATIVES OF PHOSPHOLIPIDS BY THE ENZYMATIC TECHNIQUE | MEITO SANGYO KABUSHIKI KAISHA (JP) | 1989-02-15 | — | — | EP | claimed |
| US-4783402-A | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique | MEITO SANGYO KABUSHIKI KAISHA (JP) | 1988-11-08 | — | — | US | claimed |
| EP-0122151-A2 | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique | MEITO SANGYO KABUSHIKI KAISHA (JP) | 1984-10-17 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315227-A1 | PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF | POLN, POLRMT, NUDT21 | CYP2A6 4283/4885ALOX12 2506/4885CYP1A2 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.