Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 7/20 | 0.47 |
| ▸ | SLC5A2 | P31639 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25044749 | 0.85 | SLC5A1 (0.46) | SLC5A1SLC5A2TP53ALOX12SMN1; SMN2 | |
| SCHEMBL25044743 | 0.85 | SLC5A1 (0.57) | SLC5A1SLC5A2TP53ALOX12SMN1; SMN2 | |
| SCHEMBL25043826 | 0.85 | SMN1; SMN2 (0.48) | SLC5A1SLC5A2TP53ALOX12SMN1; SMN2 | |
| SCHEMBL15897976 | 0.84 | CA12 (0.53) | SLC5A1SLC5A2TP53ALOX12SMN1; SMN2 | |
| SCHEMBL25044704 | 0.83 | SLC5A1 (0.42) | SLC5A1SLC5A2TP53ALOX12SMN1; SMN2 | |
| SCHEMBL14710979 | 0.83 | SLC5A1 (0.59) | SLC5A1SLC5A2TP53ALOX12SMN1; SMN2 | |
| SCHEMBL25045387 | 0.83 | KMT2A (0.56) | SLC5A1SLC5A2TP53ALOX12SMN1; SMN2 | |
| SCHEMBL30282905 | 0.83 | TP53 (0.49) | SLC5A1SLC5A2TP53ALOX12SMN1; SMN2 | |
| SCHEMBL20028111 | 0.82 | TP53 (0.66) | SLC5A1SLC5A2TP53ALOX12SMN1; SMN2 | |
| SCHEMBL31297182 | 0.82 | HTT (0.41) | SLC5A1SLC5A2TP53ALOX12KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112424197-B | Difluoromethyl-phenyltriazoles as modulators of GABA receptors | 勃林格殷格翰国际公司 | 2025-04-22 | — | — | CN | disclosed |
| CN-115703765-B | Substituted triazole derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2025-02-28 | — | — | CN | disclosed |
| WO-2024251133-A1 | HETEROCYCLIC COMPOUND AS α5-GABAA RECEPTOR MODULATOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2024-12-12 | — | — | WO | disclosed |
| CN-119080754-A | As alpha 5-GABAAHeterocyclic compounds of receptor modulators and uses thereof | 武汉人福创新药物研发中心有限公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-115703765-A | Substituted triazole derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2023-02-17 | — | — | CN | disclosed |
| WO-2023016521-A1 | SUBSTITUTED TRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 上海赛默罗生物科技有限公司 | 2023-02-16 | — | — | WO | disclosed |
| EP-3823967-B1 | DIFLUOROMETHYL-PHENYL TRIAZOLES AS GABA RECEPTOR MODULATORS | BOEHRINGER INGELHEIM INT (DE) | 2022-08-31 | — | — | EP | disclosed |
| EP-3823967-A1 | DIFLUOROMETHYL-PHENYL TRIAZOLES AS GABA RECEPTOR MODULATORS | Boehringer Ingelheim International GmbH (DE) | 2021-05-26 | — | — | EP | disclosed |
| US-20210147393-A1 | DIFLUOROMETHYL-PHENYL TRIAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-05-20 | — | — | US | disclosed |
| US-20210147393-A1 | DIFLUOROMETHYL-PHENYL TRIAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-05-20 | — | — | US | disclosed |
| US-10941137-B2 | Difluoromethyl-phenyl triazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-03-09 | — | — | US | disclosed |
| US-10941137-B2 | Difluoromethyl-phenyl triazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-03-09 | — | — | US | disclosed |
| CN-112424197-A | Difluoromethyl-phenyl triazoles as GABA receptor modulators | 勃林格殷格翰国际公司 | 2021-02-26 | — | — | CN | disclosed |
| WO-2020016443-A1 | DIFLUOROMETHYL-PHENYL TRIAZOLES AS GABA RECEPTOR MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-01-23 | — | — | WO | disclosed |
| WO-2020016443-A1 | DIFLUOROMETHYL-PHENYL TRIAZOLES AS GABA RECEPTOR MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10941137-B2 | Difluoromethyl-phenyl triazoles | GABRA5, GABRB1, GABRA1 | SLC5A1 658/4885SLC5A2 1304/4885TP53 4833/4885 |
| US-20210147393-A1 | DIFLUOROMETHYL-PHENYL TRIAZOLES | GABRA5, GABRB1, GABRA1 | SLC5A1 549/4885SLC5A2 1240/4885TP53 4838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.