Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | FES | P07332 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27893617 | 0.85 | BRD4 (0.34) | DYRK1AFGFR1KDRPLK4AURKA | |
| SCHEMBL10260194 | 0.84 | DYRK1A (0.40) | DYRK1AFGFR1KDRPLK4AURKA | |
| SCHEMBL1357872 | 0.84 | MET (0.40) | DYRK1AFGFR1KDRPLK4AURKA | |
| SCHEMBL859235 | 0.81 | BRAF (0.35) | DYRK1AFGFR1KDRPLK4AURKA | |
| SCHEMBL858321 | 0.80 | BRAF (0.37) | DYRK1AFGFR1KDRPLK4AURKA | |
| SCHEMBL21626895 | 0.79 | CHEK1 (0.32) | FGFR1KDRAURKBKITNTRK1 | |
| SCHEMBL10268093 | 0.79 | DYRK1A (0.40) | DYRK1AFGFR1KDRPLK4AURKA | |
| SCHEMBL21626843 | 0.78 | F2 (0.39) | DYRK1AKITMAP3K11AAK1LRRK2 | |
| SCHEMBL859205 | 0.78 | MTNR1A (0.39) | DYRK1AFGFR1KDRPLK4AURKA | |
| SCHEMBL858698 | 0.78 | JAK2 (0.39) | DYRK1AFGFR1KDRPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322760-A1 | CRYSTAL FORM OF AZAINDOLE DERIVATIVE AND USE THEREOF | WUXI LIFE FOUNTAIN BIOTECH CO., LTD (CN) | 2023-10-12 | — | — | US | disclosed |
| US-20210253571-A1 | AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR | WUXI LIFE FOUNTAIN BIOTECH CO., LTD (CN) | 2021-08-19 | — | — | US | disclosed |
| EP-3825314-A1 | AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR | Medshine Discovery Inc. (CN) | 2021-05-26 | — | — | EP | disclosed |
| WO-2020015744-A1 | AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR | 南京明德新药研发有限公司 | 2020-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322760-A1 | CRYSTAL FORM OF AZAINDOLE DERIVATIVE AND USE THEREOF | AZI2, GDI2, GDI1 | DYRK1A 1872/4885FGFR1 4731/4885KDR 4046/4885 |
| US-20210253571-A1 | AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR | MET, FGFR1, FGFR2 | DYRK1A 542/4885FGFR1 2/4885KDR 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.