SCHEMBL21628752

SCHEMBL21628752

CCc1ccc(Oc2ccc(C(N)=O)cn2)cc1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 13/20 0.67
OPRK1 P41145 12/20 0.67
OPRD1 P41143 7/20 0.67
GRIN2D O15399 1/20 0.60
GRIN3B O60391 1/20 0.60
SLC6A2 P23975 1/20 0.60
SLC6A3 Q01959 1/20 0.60
GRIN1 Q05586 1/20 0.60
KCNH2 Q12809 1/20 0.60
GRIN2A Q12879 1/20 0.60
GRIN2B Q13224 1/20 0.60
ROCK1 Q13464 1/20 0.60
GRIN2C Q14957 1/20 0.60
GRIN3A Q8TCU5 1/20 0.60
NNMT P40261 2/20 0.56
ABCB1 P08183 1/20 0.53
P2RX3 P56373 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13285698 0.89 OPRM1 (0.68) OPRM1OPRK1OPRD1GRIN2DGRIN3B
SCHEMBL21656511 0.87 MAPT (0.60) OPRM1OPRK1OPRD1GRIN2DGRIN3B
SCHEMBL20844557 0.87 OPRM1 (0.51) OPRM1OPRK1OPRD1GRIN2DGRIN3B
SCHEMBL21628606 0.87 OPRM1 (0.67) OPRM1OPRK1OPRD1GRIN2DGRIN3B
SCHEMBL3693246 0.86 OPRM1 (0.64) OPRM1OPRK1OPRD1GRIN2DGRIN3B
SCHEMBL21656974 0.86 LMNA (0.60) OPRM1OPRK1OPRD1GRIN2DGRIN3B
SCHEMBL21628719 0.85 OPRM1 (0.65) OPRM1OPRK1OPRD1GRIN2DGRIN3B
SCHEMBL3697702 0.84 OPRM1 (0.70) OPRM1OPRK1OPRD1GRIN2DGRIN3B
SCHEMBL20482160 0.84 PDE4B (0.57) OPRM1OPRK1OPRD1GRIN2DGRIN3B
SCHEMBL3693434 0.84 OPRM1 (0.70) OPRM1OPRK1OPRD1GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 US disclosed
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-12-21 US disclosed
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-05-18 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2022-11-03 US disclosed
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2021-04-15 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK OPRM1 3978/4885OPRK1 2780/4885OPRD1 2899/4885
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK OPRM1 3978/4885OPRK1 2780/4885OPRD1 2899/4885
US-11591289-B2 Aromatic compounds AHR, TYR, MUSK OPRM1 4075/4885OPRK1 3124/4885OPRD1 3247/4885
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK OPRM1 3978/4885OPRK1 2780/4885OPRD1 2899/4885
US-12600696-B2 Aromatic compounds CCR1, CCRL2, AHR OPRM1 817/4885OPRK1 684/4885OPRD1 706/4885
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK OPRM1 3978/4885OPRK1 2780/4885OPRD1 2899/4885
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK OPRM1 3978/4885OPRK1 2780/4885OPRD1 2899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.