SCHEMBL21628762

SCHEMBL21628762

CNC(=O)c1cnc(Oc2ccc(C3CC3)cc2)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 1/20 0.43
HPGDS O60760 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
HTT P42858 1/20 0.41
SCN9A Q15858 3/20 0.41
HRH3 Q9Y5N1 2/20 0.38
MMP13 P45452 1/20 0.38
MAPK14 Q16539 1/20 0.37
GCK P35557 1/20 0.37
FGFR1 P11362 1/20 0.37
SCN8A Q9UQD0 1/20 0.37
SCN10A Q9Y5Y9 1/20 0.37
PDE4A P27815 1/20 0.37
PDE4B Q07343 1/20 0.37
PDE4D Q08499 1/20 0.37
ACACB O00763 1/20 0.37
MET P08581 2/20 0.36
AXL P30530 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21628704 0.95 SCN9A (0.45) CSF1RHPGDSSMN1; SMN2HPGDTSHR
SCHEMBL21656946 0.95 SCN9A (0.43) CSF1RHPGDSSMN1; SMN2HPGDTSHR
SCHEMBL21628435 0.94 SCN9A (0.45) CSF1RHPGDSSMN1; SMN2HPGDTSHR
SCHEMBL21628784 0.94 SCN9A (0.45) CSF1RHPGDSSMN1; SMN2HPGDTSHR
SCHEMBL21628554 0.89 HDAC6 (0.45) SMN1; SMN2SCN8ASCN10APDE4APDE4B
SCHEMBL21628578 0.87 ALOX5AP (0.40) CSF1RTSHRSCN9AMAPK14ACACB
SCHEMBL21628617 0.85 MRGPRX4 (0.46)
SCHEMBL21628739 0.85 HDAC6 (0.52)
SCHEMBL21628664 0.85 HDAC6 (0.49)
SCHEMBL21628849 0.84 PARP10 (0.47) HPGDS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 US disclosed
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-12-21 US disclosed
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-05-18 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2022-11-03 US disclosed
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2021-04-15 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK CSF1R 1661/4885HPGDS 274/4885SMN1; SMN2 796/4885
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK CSF1R 1661/4885HPGDS 274/4885SMN1; SMN2 796/4885
US-11591289-B2 Aromatic compounds AHR, TYR, MUSK CSF1R 1498/4885HPGDS 132/4885SMN1; SMN2 1107/4885
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK CSF1R 1661/4885HPGDS 274/4885SMN1; SMN2 796/4885
US-12600696-B2 Aromatic compounds CCR1, CCRL2, AHR CSF1R 1877/4885HPGDS 772/4885SMN1; SMN2 919/4885
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK CSF1R 1661/4885HPGDS 274/4885SMN1; SMN2 796/4885
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK CSF1R 1661/4885HPGDS 274/4885SMN1; SMN2 796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.