Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399302 | 0.89 | PTGDR2 (0.57) | PTGDR2KDM4EHSD17B10HPGDUSP2 | |
| SCHEMBL22408775 | 0.82 | APEX1 (0.42) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL3982874 | 0.81 | PTGDR2 (0.62) | PTGDR2KDM4EUSP2ALPLALOX15 | |
| SCHEMBL29637887 | 0.78 | KDM4E (0.51) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL23388820 | 0.76 | ALDH1A1 (0.50) | KDM4EHSD17B10HPGDALOX15ALDH1A1 | |
| SCHEMBL29750502 | 0.76 | ALDH1A1 (0.50) | KDM4EHSD17B10HPGDALOX15ALDH1A1 | |
| SCHEMBL26667049 | 0.74 | HPGD (0.48) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL2569698 | 0.74 | ALDH1A1 (0.48) | KDM4EHSD17B10HPGDALOX15ALDH1A1 | |
| SCHEMBL15504737 | 0.74 | KDM4E (0.35) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL16217687 | 0.73 | PTGDR2 (0.57) | PTGDR2USP2ALPLALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10759721-B2 | Deuterated CFTR potentiators | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2020-09-01 | — | — | US | disclosed |
| US-20200031776-A1 | DEUTERATED CFTR POTENTIATORS | CONCERT PHARMACEUTICALS, INC. | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031776-A1 | DEUTERATED CFTR POTENTIATORS | CFTR, SLC26A3, SLC26A4 | PTGDR2 497/4885KDM4E 4813/4885HSD17B10 1798/4885 |
| US-10759721-B2 | Deuterated CFTR potentiators | CFTR, SLC26A3, SLC26A4 | PTGDR2 497/4885KDM4E 4813/4885HSD17B10 1798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.