SCHEMBL399302

SCHEMBL399302

COC(=O)Oc1ccc(Br)cc1C(C)(C)C

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.57
USP2 O75604 1/20 0.46
ALPL P05186 1/20 0.46
ALOX15 P16050 1/20 0.46
KDM4E B2RXH2 4/20 0.42
HSD17B10 Q99714 3/20 0.42
HPGD P15428 1/20 0.42
RBP4 P02753 1/20 0.42
SMN1; SMN2 Q16637 6/20 0.40
ALDH1A1 P00352 4/20 0.40
MAPT P10636 3/20 0.40
HTT P42858 2/20 0.40
JAK2 O60674 1/20 0.40
GAA P10253 1/20 0.40
LMNA P02545 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
NCEH1 Q6PIU2 2/20 0.38
NPC1 O15118 1/20 0.38
MAPK1 P28482 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3982874 0.92 PTGDR2 (0.62) PTGDR2USP2ALPLALOX15KDM4E
SCHEMBL21629618 0.89 PTGDR2 (0.47) PTGDR2USP2ALPLALOX15KDM4E
SCHEMBL3982876 0.83 PTGDR2 (0.65) PTGDR2USP2ALPLALOX15KDM4E
SCHEMBL16217687 0.83 PTGDR2 (0.57) PTGDR2USP2ALPLALOX15RBP4
SCHEMBL29798808 0.82 APEX1 (0.48) PTGDR2KDM4EHSD17B10HPGDSMN1; SMN2
SCHEMBL377171 0.82 APEX1 (0.48) PTGDR2KDM4EHSD17B10HPGDSMN1; SMN2
SCHEMBL25261611 0.81 ALDH1A1 (0.52) ALDH1A1MAPTHTTGAA
SCHEMBL394551 0.81 RBP4 (0.46) PTGDR2KDM4EHSD17B10HPGDRBP4
SCHEMBL23388820 0.80 ALDH1A1 (0.50) ALOX15KDM4EHSD17B10HPGDSMN1; SMN2
SCHEMBL29750502 0.80 ALDH1A1 (0.50) ALOX15KDM4EHSD17B10HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078136-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR PROTEOSTASIS THERAPEUTICS INC (US) 2026-03-19 US disclosed
EP-3691638-B1 COMPOUNDS, COMPOSITIONS AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS INC (US) 2024-12-11 EP disclosed
US-20240368198-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR PROTEOSTASIS THERAPEUTICS INC (US) 2024-11-07 US disclosed
US-20240109922-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR PROTEOSTASIS THERAPEUTICS INC (US) 2024-04-04 US disclosed
US-11248010-B2 Compounds, compositions, and methods for modulating CFTR PROTEOSTASIS THERAPEUTICS, INC. (US) 2022-02-15 US disclosed
US-20210369749-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS INC (US) 2021-12-02 US disclosed
EP-3440057-B1 SILICONE ATOMS CONTAINING IVACAFTOR ANALOGUES PROTEOSTASIS THERAPEUTICS INC (US) 2021-09-22 EP disclosed
US-20210061823-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR PROTEOSTASIS THERAPEUTICS, INC. 2021-03-04 US disclosed
EP-3691638-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR INCREASING CFTR ACTIVITY Proteostasis Therapeutics, Inc. (US) 2020-08-12 EP disclosed
US-10662207-B2 Compounds, compositions, and methods for modulating CFTR PROTEOSTASIS THERAPEUTICS, INC. (US) 2020-05-26 US disclosed
US-20090298876-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-12-03 US disclosed
US-20090298876-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-12-03 US disclosed
US-20090246820-A1 COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH VERTEX PHARMACEUTICALS INCORPORATED 2009-10-01 US disclosed
US-20090246820-A1 COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH VERTEX PHARMACEUTICALS INCORPORATED 2009-10-01 US disclosed
US-20090227797-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-09-10 US disclosed
US-20090227797-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-09-10 US disclosed
US-7495103-B2 Modulators of ATP-binding cassette transporters VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-02-24 US disclosed
US-7495103-B2 Modulators of ATP-binding cassette transporters VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-02-24 US disclosed
US-20080071095-A1 Cystic fibrosis transmembrane conductance VERTEX PHARMACEUTICALS INCORPORATED (US) 2008-03-20 US disclosed
US-20080071095-A1 Cystic fibrosis transmembrane conductance VERTEX PHARMACEUTICALS INCORPORATED (US) 2008-03-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109922-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR CFTR, SCNN1B, SCNN1G PTGDR2 2306/4885USP2 2654/4885ALPL 4652/4885
US-20210369749-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY CFTR, ABCB4, ATP5ME PTGDR2 3603/4885USP2 702/4885ALPL 4675/4885
US-20240368198-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR CFTR, SCNN1B, SCNN1G PTGDR2 2306/4885USP2 2654/4885ALPL 4652/4885
US-11248010-B2 Compounds, compositions, and methods for modulating CFTR CFTR, SCNN1B, SCNN1G PTGDR2 2306/4885USP2 2654/4885ALPL 4652/4885
US-20090227797-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 PTGDR2 2134/4885USP2 2773/4885ALPL 4794/4885
US-20090298876-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 PTGDR2 2134/4885USP2 2773/4885ALPL 4794/4885
US-20210061823-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR CFTR, SCNN1B, SCNN1G PTGDR2 2306/4885USP2 2654/4885ALPL 4652/4885
US-20080071095-A1 Cystic fibrosis transmembrane conductance CFTR, ABCB1, ABCC1 PTGDR2 1831/4885USP2 2831/4885ALPL 4811/4885
US-20260078136-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR CFTR, SCNN1B, SCNN1A PTGDR2 2378/4885USP2 3061/4885ALPL 4688/4885
US-10662207-B2 Compounds, compositions, and methods for modulating CFTR CFTR, SCNN1B, SCNN1G PTGDR2 2306/4885USP2 2654/4885ALPL 4652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.