SCHEMBL216347

SCHEMBL216347

[CH2]CCc1ccc(OC)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.61
MAOB P27338 2/20 0.55
CALM1 P0DP23 2/20 0.55
IDO1 P14902 2/20 0.54
ALDH1A1 P00352 1/20 0.54
TP53 P04637 1/20 0.54
CYP3A4 P08684 1/20 0.54
ALOX15 P16050 1/20 0.54
TSHR P16473 1/20 0.54
ALOX12 P18054 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
AOC3 Q16853 2/20 0.53
SIGMAR1 Q99720 1/20 0.53
CA12 O43570 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
F2RL1 P55085 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6625055 0.94 MAOB (0.66) TAAR1MAOBCALM1IDO1ALDH1A1
Zinc Chloride SCHEMBL29127871 0.92 TAAR1 (0.53) TAAR1MAOBCALM1IDO1ALDH1A1
SCHEMBL6627365 0.90 TAAR1 (0.52) TAAR1MAOBCALM1IDO1ALDH1A1
SCHEMBL1119420 0.86 CALM1 (0.62) TAAR1MAOBCALM1IDO1ALDH1A1
SCHEMBL834551 0.85 TAAR1 (0.73) TAAR1MAOBCALM1IDO1AOC3
SCHEMBL1119607 0.85 CALM1 (0.60) TAAR1MAOBCALM1IDO1ALDH1A1
SCHEMBL1006233 0.83 CALM1 (0.58) TAAR1MAOBCALM1IDO1ALDH1A1
SCHEMBL7730468 0.83 CALM1 (0.58) TAAR1MAOBCALM1IDO1ALDH1A1
SCHEMBL1119461 0.83 CALM1 (0.58) TAAR1MAOBCALM1IDO1ALDH1A1
SCHEMBL9021362 0.81 TAAR1 (0.52) TAAR1MAOBCALM1IDO1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1779 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117384079-B Chiral N-alkyl indole compound and preparation method and application thereof 云南大学 2024-05-24 CN claimed
CN-117384079-A Chiral N-alkyl indole compound and preparation method and application thereof 云南大学 2024-01-12 CN claimed
CN-108948029-A Phenanthridinone derivative, and synthesis method and anti-tumor application thereof 华中科技大学 2018-12-07 CN claimed
CN-106810497-A Quinoline amide compound and preparation method and application 中国农业大学 2017-06-09 CN claimed
CN-106458868-A Guanidine compounds and uses thereof 伊谬诺米特医疗有限公司 2017-02-22 CN claimed
CN-105037211-A Threonyl amine carbamate derivative and application UNIV NANKAI 2015-11-11 CN claimed
US-20140100194-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA, NV (BE) 2014-04-10 US claimed
US-8558011-B2 Cold menthol receptor-1 antagonists JANSSEN PHARMACEUTICA, NV (BE) 2013-10-15 US claimed
EP-2029614-B1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2013-01-23 EP claimed
US-20120053347-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2012-03-01 US claimed
WO-1996006074-A1 METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1996-02-29 WO claimed
WO-1995019956-A1 METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1995-07-27 WO claimed
WO-1994027965-A1 NOVEL 1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS SYNTEX (U.S.A.) INC. (US) 1994-12-08 WO claimed
EP-0584223-A1 NOVEL IMMUNOSUPPRESSIVE COMPOUNDS VERTEX PHARMACEUTICALS INCORPORATED (US) 1994-03-02 EP claimed
WO-1992019593-A1 NOVEL IMMUNOSUPPRESSIVE COMPOUNDS VERTEX PHARMACEUTICALS INCORPORATED (US) 1992-11-12 WO claimed
US-5073547-A DOPAMINE PRO-DRUG SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) 1991-12-17 US claimed
US-5047399-A Hypotensive Agents SCHERING CORPORATION (US) 1991-09-10 US claimed
US-4769493-A Process for producing tetrafluorophthalic acid SDS BIOTECH K.K. (JP) 1988-09-06 US claimed
EP-0259663-A1 Process for producing tetrafluorophihalic acid SDS Biotech K.K. (JP) 1988-03-16 EP claimed
US-4537890-A 2-(3,5-Substituted-2-pyridylalkylamino)-5-oxopyridylmethyl-4-pyrimidones useful as histamine H1 -antagonists SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1985-08-27 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120053347-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 TAAR1 171/4885MAOB 2313/4885CALM1 135/4885
US-20140100194-A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS TRPM8, TRPM5, TRPM7 TAAR1 171/4885MAOB 2313/4885CALM1 135/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.