Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 11/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21635714 | 0.76 | ADAM17 (0.59) | ADAM17ADAMTS5 | |
| SCHEMBL19691621 | 0.75 | ADAM17 (0.80) | ADAM17ADAMTS5 | |
| SCHEMBL19702769 | 0.70 | ADAM17 (0.64) | ADAM17ADAMTS5 | |
| SCHEMBL19703131 | 0.68 | ADAM17 (0.48) | ADAM17 | |
| SCHEMBL19691907 | 0.67 | ADAM17 (1.00) | ADAM17ADAMTS5 | |
| SCHEMBL22063670 | 0.66 | ADAM17 (0.74) | ADAM17ADAMTS5 | |
| SCHEMBL21424839 | 0.66 | ADAM17 (0.64) | ADAM17ADAMTS5 | |
| SCHEMBL19703148 | 0.66 | ADAM17 (0.55) | ADAM17ADAMTS5 | |
| SCHEMBL19691945 | 0.66 | ADAM17 (0.83) | ADAM17ADAMTS5 | |
| SCHEMBL21403967 | 0.65 | ADAM17 (0.91) | ADAM17ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550100-B2 | 5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis | GALAPAGOS NV (BE) | 2020-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550100-B2 | 5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis | ADAMTS5, ADAMTS4, ADAMTS1 | ADAM17 8/4885ADAMTS5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.