Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 4/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | MLX | Q9UH92 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30872271 | 0.82 | CAPN1 (0.42) | CAPN1CTSBOPRM1OPRD1BDKRB2 | |
| SCHEMBL30185030 | 0.82 | BDKRB2 (0.46) | CAPN1ITGB3ITGA2BF2OPRM1 | |
| SCHEMBL30708106 | 0.79 | CAPN1 (0.45) | CAPN1CTSBF2RENXIAP | |
| SCHEMBL12456874 | 0.78 | CAPN1 (0.43) | CAPN1CTSBF2RENACE | |
| SCHEMBL21816859 | 0.78 | PEPD (0.49) | CAPN1F2RENACEPREP | |
| SCHEMBL31206788 | 0.77 | APLNR (0.42) | CAPN1F2OPRM1OPRD1REN | |
| SCHEMBL29541526 | 0.77 | ITGB3 (0.40) | CAPN1ITGB3ITGA2BCTSBF2 | |
| SCHEMBL21581703 | 0.76 | CAPN1 (0.45) | CAPN1CTSBF2OPRM1OPRD1 | |
| SCHEMBL26454162 | 0.76 | CAPN1 (0.45) | CAPN1CTSBF2OPRM1OPRD1 | |
| SCHEMBL21581704 | 0.75 | FKBP5 (0.44) | CAPN1CTSBF2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210187111-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | SCRIPPS HEALTH (US) | 2021-06-24 | — | — | US | disclosed |
| WO-2020018434-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | SCRIPPS HEALTH (US) | 2020-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210187111-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | MSR1, CD68, CD209 | CAPN1 2208/4885ITGB3 629/4885ITGA2B 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.