Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878800 | 0.71 | CHRM3 (0.59) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL15955100 | 0.70 | MAPT (0.57) | HDAC3HDAC1HDAC2KMT2ACYP2D6 | |
| SCHEMBL7972743 | 0.70 | ITGB3 (0.51) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL27626467 | 0.69 | KMT2A (0.54) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL11251566 | 0.68 | KMT2A (0.68) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL6230136 | 0.67 | TNKS2 (0.45) | HDAC3HDAC1HDAC2LMNAITGB3 | |
| SCHEMBL27726277 | 0.67 | MAPT (0.52) | HDAC3HDAC1HDAC2KMT2AMAPT | |
| SCHEMBL6665160 | 0.67 | TDP1 (0.63) | HDAC3HDAC1HDAC2KMT2AMEN1 | |
| SCHEMBL20556104 | 0.67 | MEN1 (0.38) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL954535 | 0.67 | ITGB3 (0.56) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210187111-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | SCRIPPS HEALTH (US) | 2021-06-24 | — | — | US | disclosed |
| WO-2020018434-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | SCRIPPS HEALTH (US) | 2020-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210187111-A1 | COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK | MSR1, CD68, CD209 | HDAC3 536/4885HDAC1 710/4885HDAC2 1374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.