Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 13/20 | 0.51 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.49 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.49 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL393075 | 0.85 | S1PR3 (0.51) | S1PR3TRPV4KCNQ3KCNQ2KCNE1 | |
| Hydrochloric Acid SCHEMBL6518510 | 0.83 | S1PR3 (0.50) | S1PR3TRPV4KCNQ3KCNQ2KCNE1 | |
| SCHEMBL1953476 | 0.83 | CYP11B2 (0.60) | S1PR3TRPV4KCNQ3KCNQ2KCNE1 | |
| SCHEMBL15464961 | 0.83 | CYP11B2 (0.60) | S1PR3TRPV4KCNQ3KCNQ2KCNE1 | |
| SCHEMBL1274914 | 0.83 | KCNQ3 (0.55) | S1PR3TRPV4KCNQ3KCNQ2KCNE1 | |
| SCHEMBL26447291 | 0.80 | S1PR3 (0.48) | S1PR3TRPV4KCNQ3KCNQ2KCNE1 | |
| SCHEMBL1275177 | 0.79 | TRPA1 (0.51) | S1PR3TRPV4KCNQ3KCNQ2KCNE1 | |
| SCHEMBL12670890 | 0.79 | S1PR3 (0.57) | S1PR3KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL26447058 | 0.79 | S1PR3 (0.50) | S1PR3TRPV4KCNQ3KCNQ2KCNE1 | |
| SCHEMBL393951 | 0.79 | GSK3B (0.54) | S1PR3TRPV4KCNQ3KCNQ2KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | THE KITASATO INSTITUTE (JP) | 2011-07-28 | — | — | US | claimed |
| EP-2228376-A1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | The Kitasato Institute (JP) | 2010-09-15 | — | — | EP | claimed |
| EP-2228376-B1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | KITASATO INST (JP) | 2015-06-03 | — | — | EP | disclosed |
| US-8519128-B2 | Pyripyropene derivatives having an ACAT2-inhibiting activity | THE KITASATO INSTITUTE (JP) | 2013-08-27 | — | — | US | disclosed |
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | THE KITASATO INSTITUTE (JP) | 2011-07-28 | — | — | US | disclosed |
| EP-2228376-A1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | The Kitasato Institute (JP) | 2010-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | ACAT2, ACAT1, AGPAT2 | S1PR3 2973/4885TRPV4 1118/4885KCNQ3 2055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.