SCHEMBL21640952

SCHEMBL21640952

CSc1nc(C)c(C(=O)O)c(Cl)n1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
MAPK1 P28482 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
PPARG P37231 4/20 0.44
AHR P35869 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35
PDE10A Q9Y233 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
FABP3 P05413 1/20 0.34
FABP4 P15090 1/20 0.34
NPC1 O15118 1/20 0.34
KDM4E B2RXH2 1/20 0.34
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
POLB P06746 1/20 0.33
DHODH Q02127 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL282501 0.88 SMN1; SMN2 (0.47) ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A
SCHEMBL3282837 0.86 PPARG (0.45) ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A
SCHEMBL26890504 0.85 PPARG (0.38) ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A
SCHEMBL24785780 0.81 TSHR (0.42) ALDH1A1SMN1; SMN2MEN1KMT2APPARG
SCHEMBL900020 0.79 PPARG (0.42) ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A
SCHEMBL1298575 0.78 LMNA (0.44) ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A
SCHEMBL31207901 0.78 LMNA (0.44) ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A
SCHEMBL31207902 0.78 LMNA (0.44) ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A
SCHEMBL4980053 0.77 KMT2A (0.40) ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A
SCHEMBL20067834 0.76 PPARG (0.41) ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3604305-B1 NOVEL PYRIDONE CARBOXYLIC ACID DERIVATIVE OR SALT THEREOF WAKUNAGA PHARMA CO LTD (JP) 2024-08-28 EP disclosed
CN-110520422-B Novel pyridonecarboxylic acid derivative or salt thereof 涌永制药株式会社 2023-09-05 CN disclosed
US-11286255-B2 Pyridone carboxylic acid derivative or salt thereof WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) 2022-03-29 US disclosed
US-20200062752-A1 NOVEL PYRIDONE CARBOXYLIC ACID DERIVATIVE OR SALT THEREOF WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) 2020-02-27 US disclosed
EP-3604305-A1 NOVEL PYRIDONE CARBOXYLIC ACID DERIVATIVE OR SALT THEREOF Wakunaga Pharmaceutical Co., Ltd. (JP) 2020-02-05 EP disclosed
CN-110520422-A Novel pyridone carboxylic acid derivatives or its salt WAKUNAGA PHARMA CO LTD 2019-11-29 CN disclosed
CN-102695416-B Kinase inhibitor 金纳斯克公司 2017-03-08 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200062752-A1 NOVEL PYRIDONE CARBOXYLIC ACID DERIVATIVE OR SALT THEREOF RAB10, HDAC10, NEK10 ALDH1A1 207/4885MAPK1 144/4885SMN1; SMN2 3320/4885
US-11286255-B2 Pyridone carboxylic acid derivative or salt thereof RARA, RAB10, RABL6 ALDH1A1 81/4885MAPK1 143/4885SMN1; SMN2 3701/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.