Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 12/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 12/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21645474 | 1.00 | FAAH (0.48) | FAAHHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5127855 | 0.90 | FAAH (0.48) | FAAHHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4409723 | 0.77 | CTSK (0.49) | HDAC4HDAC1HDAC6ITGB3ITGA2B | |
| SCHEMBL19668435 | 0.77 | CTSK (0.49) | HDAC4HDAC1HDAC6ITGB3ITGA2B | |
| SCHEMBL31072330 | 0.77 | CTSK (0.49) | HDAC4HDAC1HDAC6ITGB3ITGA2B | |
| SCHEMBL14150791 | 0.77 | CTSK (0.56) | HDAC4HDAC1HDAC6ITGB3ITGA2B | |
| SCHEMBL6745774 | 0.77 | CTSK (0.56) | HDAC4HDAC1HDAC6ITGB3ITGA2B | |
| SCHEMBL25277595 | 0.77 | ITGB3 (0.51) | HDAC8ITGB3ITGA2B | |
| SCHEMBL30801969 | 0.77 | ITGB3 (0.51) | HDAC8ITGB3ITGA2B | |
| SCHEMBL21645736 | 0.76 | FAAH (0.45) | FAAHHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3829559-B1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | MERCK SHARP & DOHME LLC (US) | 2026-05-13 | — | — | EP | disclosed |
| US-12331044-B2 | Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection | MERCK SHARP & DOHME LLC (US) | 2025-06-17 | — | — | US | disclosed |
| US-20210276992-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | MERCK SHARP & DOHME CORP. (US) | 2021-09-09 | — | — | US | disclosed |
| EP-3829559-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | Merck Sharp & Dohme Corp. (US) | 2021-06-09 | — | — | EP | disclosed |
| WO-2020028150-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | MERCK SHARP & DOHME CORP. (US) | 2020-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12331044-B2 | Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection | HDAC1, HDAC11, HDAC10 | FAAH 2340/4885HDAC3 4/4885HDAC4 9/4885 |
| US-20210276992-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | HDAC1, HDAC11, HDAC10 | FAAH 2340/4885HDAC3 4/4885HDAC4 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.