Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Danitracen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.75 |
| ▸ | SETD7 | Q8WTS6 | 7/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.75 |
| ▸ | HTR1A | P08908 | 4/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.75 |
| ▸ | DRD1 | P21728 | 4/20 | 0.75 |
| ▸ | DRD3 | P35462 | 4/20 | 0.75 |
| ▸ | HTR2A | P28223 | 4/20 | 0.75 |
| ▸ | HTR2C | P28335 | 4/20 | 0.75 |
| ▸ | HTR2B | P41595 | 4/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.75 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.75 |
| ▸ | DRD2 | P14416 | 3/20 | 0.75 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Danitracen SCHEMBL29387690 | 0.91 | SETD7 (0.67) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Danitracen SCHEMBL2734228 | 0.91 | SETD7 (0.67) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL29369949 | 0.87 | SETD7 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL4021 | 0.87 | SETD7 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL7923153 | 0.87 | SETD7 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL41842 | 0.85 | LMNA (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL20610743 | 0.85 | LMNA (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL30772122 | 0.85 | LMNA (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL5500354 | 0.85 | LMNA (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Cyproheptadine SCHEMBL29380652 | 0.85 | LMNA (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210308052-A1 | SUSTAINED-RELEASE COMPOSITIONS COMPRISING A THERAPEUTIC AGENT FOR TREATING DEPRESSION OR ANXIETY AND USES THEREOF | TAIWAN LIPOSOME CO., LTD. (TW) | 2021-10-07 | — | — | US | claimed |
| EP-3829539-A1 | SUSTAINED-RELEASE COMPOSITIONS COMPRISING A THERAPEUTIC AGENT FOR TREATING DEPRESSION OR ANXIETY AND USES THEREOF | Taiwan Liposome Company, Ltd. (TW) | 2021-06-09 | — | — | EP | claimed |
| WO-2020028475-A1 | SUSTAINED-RELEASE COMPOSITIONS COMPRISING A THERAPEUTIC AGENT FOR TREATING DEPRESSION OR ANXIETY AND USES THEREOF | TAIWAN LIPOSOME CO., LTD. (CN) | 2020-02-06 | — | — | WO | claimed |
| US-12005142-B2 | Sustained-release compositions comprising a therapeutic agent for treating depression or anxiety and uses thereof | TAIWAN LIPOSOME CO., LTD. (TW) | 2024-06-11 | — | — | US | disclosed |
| US-20210308052-A1 | SUSTAINED-RELEASE COMPOSITIONS COMPRISING A THERAPEUTIC AGENT FOR TREATING DEPRESSION OR ANXIETY AND USES THEREOF | TAIWAN LIPOSOME CO., LTD. (TW) | 2021-10-07 | — | — | US | disclosed |
| EP-3829539-A1 | SUSTAINED-RELEASE COMPOSITIONS COMPRISING A THERAPEUTIC AGENT FOR TREATING DEPRESSION OR ANXIETY AND USES THEREOF | Taiwan Liposome Company, Ltd. (TW) | 2021-06-09 | — | — | EP | disclosed |
| WO-2020028475-A1 | SUSTAINED-RELEASE COMPOSITIONS COMPRISING A THERAPEUTIC AGENT FOR TREATING DEPRESSION OR ANXIETY AND USES THEREOF | TAIWAN LIPOSOME CO., LTD. (CN) | 2020-02-06 | — | — | WO | disclosed |