Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28933660 | 0.89 | NR1H4 (0.39) | LMNAADORA1ALDH1A1GAAHTT | |
| SCHEMBL19437381 | 0.87 | L3MBTL1 (0.41) | LMNAADORA1ALDH1A1GAAHTT | |
| SCHEMBL20983354 | 0.79 | LMNA (0.37) | LMNAADORA1ALDH1A1GAAHTT | |
| SCHEMBL28692716 | 0.78 | NR1H4 (0.47) | SMN1; SMN2NR1H2NR1H3PTGER4MAOB | |
| SCHEMBL21649780 | 0.76 | BRD4 (0.46) | — | |
| SCHEMBL19456268 | 0.76 | BRD4 (0.46) | — | |
| SCHEMBL19437263 | 0.75 | JAK2 (0.46) | ALDH1A1SMN1; SMN2NR1H2PTGER4MAOB | |
| SCHEMBL19456225 | 0.67 | BRD4 (0.54) | — | |
| SCHEMBL18731782 | 0.66 | BRD4 (0.54) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8265682 | 0.65 | ALDH1A1 (0.52) | LMNAALDH1A1KDM4ESMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440075-B1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-01-29 | — | — | EP | disclosed |