Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21652656 | 0.72 | HTT (0.47) | HTTPTK2DYRK1AMAPT | |
| SCHEMBL11709325 | 0.68 | ALDH1A1 (0.41) | HTTPTK2ACVR1PARP1MEN1 | |
| SCHEMBL26031462 | 0.68 | HTT (0.38) | HTTPTK2ALDH1A1 | |
| SCHEMBL23771325 | 0.67 | ALDH1A1 (0.50) | HTTALDH1A1 | |
| SCHEMBL26204751 | 0.66 | RET (0.43) | NOS3NOS1NOS2MEN1ALDH1A1 | |
| SCHEMBL2596852 | 0.65 | HTT (0.44) | HTTPTK2DYRK1ACYP3A4CYP2D6 | |
| SCHEMBL10570578 | 0.65 | CYP1A2 (0.44) | HTTPTK2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL17545521 | 0.65 | NOS3 (0.43) | NOS3NOS1NOS2MEN1ALDH1A1 | |
| SCHEMBL19964519 | 0.64 | HTT (0.52) | HTTPTK2NOS1ALDH1A1MAPT | |
| SCHEMBL25778111 | 0.64 | HTT (0.47) | HTTPTK2DYRK1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023551-A1 | NAPHTHYRIDINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-01-30 | — | — | WO | disclosed |