Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653231 | 0.85 | MEN1 (0.41) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL21653070 | 0.85 | MEN1 (0.44) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL21653110 | 0.81 | ALDH1A1 (0.37) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL21653096 | 0.80 | GRM1 (0.46) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL21653069 | 0.77 | ALDH1A1 (0.43) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL21653390 | 0.77 | SMN1; SMN2 (0.44) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL21653068 | 0.77 | TAS2R8 (0.47) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL21652915 | 0.76 | CREBBP (0.55) | RAB9AMEN1KMT2ANPC1TP53 | |
| SCHEMBL21652920 | 0.76 | MAPT (0.42) | RAB9AMEN1KMT2ANPC1TP53 | |
| SCHEMBL21653203 | 0.73 | SMN1; SMN2 (0.46) | RAB9ASMN1; SMN2MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |