Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653202 | 0.79 | CNR2 (0.43) | ALDH1A1KDM4EKMT2ACYP3A4CYP2C19 | |
| SCHEMBL21652915 | 0.77 | CREBBP (0.55) | HTTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL21653182 | 0.77 | KMT2A (0.52) | SMN1; SMN2TP53KDM4EMEN1KMT2A | |
| SCHEMBL21653197 | 0.77 | RAB9A (0.55) | SMN1; SMN2NPSR1HSD17B10ALDH1A1KDM4E | |
| SCHEMBL15461393 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1HTTHSD17B10TP53 | |
| SCHEMBL21653177 | 0.76 | MAPT (0.46) | SMN1; SMN2L3MBTL1NPSR1ALDH1A1KDM4E | |
| SCHEMBL21652908 | 0.76 | PSMB5 (0.46) | SMN1; SMN2HTTTP53ALDH1A1KDM4E | |
| SCHEMBL21653300 | 0.76 | PTPN1 (0.54) | SMN1; SMN2HSD17B10ALDH1A1KDM4EHPGD | |
| SCHEMBL21653069 | 0.75 | ALDH1A1 (0.43) | SMN1; SMN2NPSR1TP53ALDH1A1KDM4E | |
| SCHEMBL21652982 | 0.75 | ALDH1A1 (0.46) | L3MBTL1NPSR1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |