Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653250 | 0.88 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL21653240 | 0.87 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDL3MBTL1RAB9A | |
| SCHEMBL21653124 | 0.85 | PPARG (0.40) | KDM4EALDH1A1HPGDL3MBTL1CASP3 | |
| SCHEMBL21653140 | 0.84 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL21653122 | 0.83 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL21652912 | 0.82 | KDM4E (0.45) | KDM4EALDH1A1HPGDL3MBTL1RAB9A | |
| SCHEMBL21653230 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL21653243 | 0.80 | SMN1; SMN2 (0.44) | KDM4EALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL21653229 | 0.79 | RAB9A (0.42) | KDM4EALDH1A1HPGDL3MBTL1RAB9A | |
| SCHEMBL21653272 | 0.79 | SMN1; SMN2 (0.42) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |