Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21652915 | 0.84 | CREBBP (0.55) | MAPTCREBBPALDH1A1KDM4ECYP3A4 | |
| SCHEMBL21653177 | 0.83 | MAPT (0.46) | MAPTALDH1A1KDM4ECYP3A4CYP2C9 | |
| SCHEMBL21653182 | 0.82 | KMT2A (0.52) | MAPTKDM4ERAB9ANPC1CA9 | |
| SCHEMBL21652920 | 0.81 | MAPT (0.42) | MAPTCREBBPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21653176 | 0.81 | MEN1 (0.58) | MAPTKDM4ERAB9ANPC1POLB | |
| SCHEMBL21653070 | 0.80 | MEN1 (0.44) | MAPTALDH1A1KDM4ECYP3A4CYP2C9 | |
| SCHEMBL21653190 | 0.80 | ALDH1A1 (0.54) | MAPTALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL21653069 | 0.80 | ALDH1A1 (0.43) | MAPTALDH1A1KDM4ECYP3A4CYP2C9 | |
| SCHEMBL21653079 | 0.79 | MEN1 (0.44) | MAPTALDH1A1KDM4ECYP3A4CYP2C9 | |
| SCHEMBL21653117 | 0.79 | ALDH1A1 (0.41) | MAPTCREBBPALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |