Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653272 | 0.86 | SMN1; SMN2 (0.42) | ALDH1A1LMNAMAPTNPSR1HSD17B10 | |
| SCHEMBL21653083 | 0.82 | SMN1; SMN2 (0.39) | ALDH1A1LMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL21653071 | 0.81 | KMT2A (0.49) | ALDH1A1LMNAMAPTNPSR1MAPK1 | |
| SCHEMBL21652976 | 0.78 | GRM5 (0.51) | ALDH1A1MAPTNPSR1SMN1; SMN2NPC1 | |
| SCHEMBL21653231 | 0.78 | MEN1 (0.41) | ALDH1A1LMNAMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL21653250 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MAPTNPSR1HSD17B10SMN1; SMN2 | |
| SCHEMBL21653238 | 0.76 | SMN1; SMN2 (0.38) | ALDH1A1LMNAMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL21653230 | 0.76 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTNPSR1MAPK1 | |
| SCHEMBL21652970 | 0.76 | NPC1 (0.41) | ALDH1A1LMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL21653203 | 0.73 | SMN1; SMN2 (0.46) | ALDH1A1LMNAMAPTNPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |