Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 9/20 | 0.41 |
| ▸ | PFKFB1 | P16118 | 8/20 | 0.41 |
| ▸ | PFKFB2 | O60825 | 7/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653001 | 0.87 | PFKFB3 (0.40) | PFKFB3PFKFB1PFKFB2KDM4EALDH1A1 | |
| SCHEMBL21652993 | 0.85 | PFKFB3 (0.39) | PFKFB3PFKFB1PFKFB2KDM4EALDH1A1 | |
| SCHEMBL21653295 | 0.82 | PFKFB3 (0.55) | PFKFB3PFKFB1PFKFB2PSMB8 | |
| SCHEMBL21653296 | 0.82 | ALDH1A1 (0.38) | PFKFB3PFKFB1PFKFB2TSHRKDM4E | |
| SCHEMBL21653197 | 0.79 | RAB9A (0.55) | KDM4EALDH1A1RAB9AHPGDHSD17B10 | |
| SCHEMBL21652855 | 0.78 | PFKFB3 (0.36) | PFKFB3PFKFB1PFKFB2TSHRKDM4E | |
| SCHEMBL21653300 | 0.78 | PTPN1 (0.54) | KDM4EALDH1A1RAB9AHPGDHSD17B10 | |
| SCHEMBL21653189 | 0.76 | RAB9A (0.43) | KDM4EALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21653191 | 0.75 | NAMPT (0.41) | TSHRKDM4EALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL21652982 | 0.74 | ALDH1A1 (0.46) | TSHRKDM4EALDH1A1TYK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |