Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653197 | 0.89 | RAB9A (0.55) | ALDH1A1NAMPTRAB9ANPSR1LMNA | |
| SCHEMBL21653300 | 0.88 | PTPN1 (0.54) | ALDH1A1RAB9AHPGDKDM4E | |
| SCHEMBL21653188 | 0.83 | NAMPT (0.42) | ALDH1A1NAMPTRAB9ANPSR1MEN1 | |
| SCHEMBL21653191 | 0.82 | NAMPT (0.41) | ALDH1A1NAMPTRAB9ANPSR1MEN1 | |
| SCHEMBL21653189 | 0.81 | RAB9A (0.43) | ALDH1A1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL21652984 | 0.79 | ALOX15 (0.48) | ALDH1A1RAB9ATNKS2HPGDKDM4E | |
| SCHEMBL21652990 | 0.78 | ALDH1A1 (0.40) | ALDH1A1NAMPTRAB9ANPSR1KMT2A | |
| SCHEMBL21653202 | 0.77 | CNR2 (0.43) | ALDH1A1CNR1CNR2KMT2AACKR3 | |
| SCHEMBL17845335 | 0.76 | MEN1 (0.61) | ALDH1A1NAMPTRAB9ANPSR1MEN1 | |
| SCHEMBL21653203 | 0.75 | SMN1; SMN2 (0.46) | ALDH1A1RAB9ANPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |