Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26156075 | 0.84 | ALDH1A1 (0.32) | PTPN11 | |
| SCHEMBL21653695 | 0.82 | PTPN11 (0.35) | PTPN11 | |
| SCHEMBL21631391 | 0.79 | HTR1A (0.34) | PTPN11 | |
| SCHEMBL21653692 | 0.79 | PTPN11 (0.31) | PTPN11 | |
| SCHEMBL21653795 | 0.73 | LPL (0.32) | — | |
| SCHEMBL23508727 | 0.69 | PTPN11 (0.34) | PTPN11 | |
| SCHEMBL19489400 | 0.69 | PTPN11 (0.33) | PTPN11 | |
| SCHEMBL23683058 | 0.68 | PTPN11 (0.33) | PTPN11 | |
| SCHEMBL21631683 | 0.68 | PTPN11 (0.33) | PTPN11 | |
| SCHEMBL23229326 | 0.67 | PTPN11 (0.32) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021149817-A1 | Enhancement of anti-tumor activity of SHP2 inhibitor pyrimidinone in combination with novel cancer medicines in cancers | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-07-29 | — | — | WO | disclosed |
| WO-2020022323-A1 | HETEROBICYCLIC COMPOUNDS FOR INHIBITING THE ACTIVITY OF SHP2 | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2020-01-30 | — | — | WO | disclosed |