Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.42 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25108882 | 0.81 | MAOB (0.44) | MAOBKDM4EHTR2AHTR2CPYCR1 | |
| SCHEMBL25108872 | 0.81 | KDM4E (0.43) | HRH3HRH4NOS3NOS1NOS2 | |
| SCHEMBL25110795 | 0.81 | RORC (0.44) | HRH3HRH4NOS3NOS1NOS2 | |
| SCHEMBL24514077 | 0.80 | MAPT (0.43) | HRH3HRH4KDM4EALDH1A1HTR1D | |
| SCHEMBL14850006 | 0.77 | HRH3 (0.49) | HRH3HRH4CHIT1CHIAKDM4E | |
| SCHEMBL14924037 | 0.74 | ALDH1A1 (0.50) | HRH3MAOBALDH1A1 | |
| SCHEMBL27358331 | 0.73 | DRD2 (0.49) | HRH3 | |
| SCHEMBL3605410 | 0.73 | ALDH1A1 (0.53) | HRH3ALDH1A1HTR2AHTR2C | |
| SCHEMBL26078953 | 0.72 | ALDH1A1 (0.59) | HRH3KDM4EALDH1A1 | |
| SCHEMBL21107432 | 0.72 | PIK3CD (0.53) | HRH3NOS3NOS1NOS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550114-B2 | Kinase inhibitors and their use in cancer therapy | TECHNISCHE UNIVERSITÄT DORTMUND (DE) | 2020-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550114-B2 | Kinase inhibitors and their use in cancer therapy | MAP3K1, MAP3K19, MAP3K6 | HRH3 2900/4885HRH4 3454/4885CHIT1 4500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.