Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2736187 | 0.85 | DRD2 (0.44) | DRD2DRD4DRD3HTR2AHRH1 | |
| SCHEMBL25443768 | 0.71 | SMN1; SMN2 (0.46) | ROCK2ROCK1ALDH1A1PARP1HRH3 | |
| SCHEMBL19820512 | 0.69 | DRD2 (0.62) | DRD2DRD4DRD3HTR2AHRH1 | |
| SCHEMBL18715752 | 0.69 | DRD2 (0.36) | DRD2DRD4DRD3HTR2AHRH1 | |
| SCHEMBL7179725 | 0.69 | SLC6A3 (0.42) | DRD2HTR2AHRH1ALDH1A1RECQL | |
| SCHEMBL902615 | 0.68 | SLC6A3 (0.44) | DRD2HTR2AHRH1ALDH1A1RECQL | |
| Hydrochloric Acid SCHEMBL6090064 | 0.67 | SLC6A3 (0.43) | DRD2HTR2AHRH1ALDH1A1RECQL | |
| Hydrochloric Acid SCHEMBL16798712 | 0.67 | SLC6A3 (0.43) | DRD2HTR2AHRH1ALDH1A1RECQL | |
| SCHEMBL24673647 | 0.66 | ROCK2 (0.39) | ROCK2ROCK1ALDH1A1PARP1HRH3 | |
| SCHEMBL12028949 | 0.66 | DRD2 (0.58) | DRD2DRD4DRD3HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550114-B2 | Kinase inhibitors and their use in cancer therapy | TECHNISCHE UNIVERSITÄT DORTMUND (DE) | 2020-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550114-B2 | Kinase inhibitors and their use in cancer therapy | MAP3K1, MAP3K19, MAP3K6 | DRD2 4618/4885DRD4 4701/4885DRD3 4705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.