Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.31 |
| ▸ | MERTK | Q12866 | 2/20 | 0.31 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | IL6 | P05231 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2736187 | 0.82 | DRD2 (0.44) | DRD2DRD4DRD3HTR2AHRH1 | |
| SCHEMBL21655052 | 0.69 | DRD2 (0.47) | DRD2DRD4DRD3HTR2AHRH1 | |
| SCHEMBL20713891 | 0.66 | GPR84 (0.31) | — | |
| SCHEMBL23734436 | 0.65 | GPR84 (0.39) | — | |
| SCHEMBL23717530 | 0.65 | GPR84 (0.36) | TLR7 | |
| SCHEMBL28958743 | 0.64 | PDE10A (0.45) | DRD2DRD4DRD3LMNAHTT | |
| SCHEMBL11919146 | 0.63 | DRD4 (0.38) | DRD2DRD4DRD3LMNAIL6 | |
| SCHEMBL12643289 | 0.62 | SLC6A3 (0.43) | DRD2HTR2AHRH1TLR7 | |
| SCHEMBL7187137 | 0.62 | SLC6A3 (0.40) | DRD2HTR2AHRH1SMN1; SMN2TLR7 | |
| SCHEMBL15000428 | 0.61 | KCNH2 (0.43) | DRD2HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689353-A1 | MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS | Gilead Sciences, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| EP-3150586-A1 | MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS | Gilead Sciences, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |