SCHEMBL21656534

SCHEMBL21656534

COC(=O)c1ccc(Oc2ccc(C3CCC3)cc2)nc1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.54
ALOX5AP P20292 2/20 0.51
FEN1 P39748 2/20 0.51
POLB P06746 1/20 0.47
P2RX3 P56373 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
HRH3 Q9Y5N1 9/20 0.44
MAPK1 P28482 2/20 0.44
ALDH1A1 P00352 1/20 0.44
MAPT P10636 1/20 0.44
KCNH2 Q12809 1/20 0.43
HAO1 Q9UJM8 1/20 0.43
KDM4E B2RXH2 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21656824 0.97 LMNA (0.54) LMNAALOX5APFEN1POLBP2RX3
SCHEMBL21656826 0.96 LMNA (0.53) LMNAALOX5APFEN1POLBP2RX3
SCHEMBL21656975 0.96 LMNA (0.53) LMNAALOX5APFEN1POLBP2RX3
SCHEMBL21656531 0.95 LMNA (0.56) LMNAALOX5APFEN1POLBP2RX3
SCHEMBL21656868 0.87 PDE4B (0.53) LMNAPOLBSMN1; SMN2HRH3ALDH1A1
SCHEMBL21628672 0.86 HRH3 (0.59) POLBSMN1; SMN2HRH3KCNH2HAO1
SCHEMBL21656821 0.86 ALOX5AP (0.48) ALOX5APFEN1POLBSMN1; SMN2HRH3
SCHEMBL21628427 0.85 HDAC8 (0.57) POLBSMN1; SMN2HRH3KCNH2HAO1
SCHEMBL21628590 0.85 HRH3 (0.56) HRH3KCNH2HAO1
SCHEMBL21656805 0.84 ALDH1A1 (0.54) ALOX5APFEN1SMN1; SMN2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 US disclosed
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-05-18 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2021-04-15 US disclosed
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2021-04-15 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885ALOX5AP 3143/4885FEN1 4361/4885
US-11591289-B2 Aromatic compounds AHR, TYR, MUSK LMNA 3083/4885ALOX5AP 3337/4885FEN1 4128/4885
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885ALOX5AP 3143/4885FEN1 4361/4885
US-12600696-B2 Aromatic compounds CCR1, CCRL2, AHR LMNA 832/4885ALOX5AP 3839/4885FEN1 1122/4885
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885ALOX5AP 3143/4885FEN1 4361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.