Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sorbitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorbitol SCHEMBL628564 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL29732412 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Sorbitol SCHEMBL633334 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL4424352 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Adonitol SCHEMBL27616531 | 0.89 | LMNA (0.53) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL27797259 | 0.87 | LMNA (0.56) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Gluconic Acid SCHEMBL16370767 | 0.85 | PDE4A (0.76) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Sulfuric Acid SCHEMBL28107960 | 0.84 | LMNA (0.48) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Sulfuric Acid SCHEMBL7156175 | 0.84 | LMNA (0.48) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Sulfuric Acid SCHEMBL7156180 | 0.84 | LMNA (0.48) | LMNAL3MBTL1TDP1TP53PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385933-B1 | CULTURE MEDIUM FOR CELL GROWTH AND TRANSFECTION | LIFE TECHNOLOGIES CORP (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2351827-A1 | Culture medium for cell growth and transfection | Life Technologies Corporation (US) | 2011-08-03 | — | — | EP | disclosed |
| US-20110183375-A1 | METAL BINDING COMPOUNDS AND THEIR USE IN CELL CULTURE MEDIUM COMPOSITIONS | Life Technologies Corporation (US) | 2011-07-28 | — | — | US | disclosed |
| US-20080286868-A1 | METAL BINDING COMPOUNDS AND THEIR USE IN CELL CULTURE MEDIUM COMPOSITIONS | INVITROGEN CORPORATION (US) | 2008-11-20 | — | — | US | disclosed |
| US-6767741-B1 | THE COMPOSITIONS OBVIATE THE NEED FOR NATURALLY DERIVED METAL-BINDING PROTEINS, SUCH AS TRANSFERRIN AND CERULOPLASMIN, WHICH MAY CONTAIN BLOOD-BORNE PATHOGENS | INVITROGEN CORPORATION | 2004-07-27 | — | — | US | disclosed |