Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sorbitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorbitol SCHEMBL633334 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Sorbitol SCHEMBL2165750 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL4424352 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL29732412 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Adonitol SCHEMBL27616531 | 0.89 | LMNA (0.53) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Sulfuric Acid SCHEMBL7156175 | 0.89 | LMNA (0.48) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL28118105 | 0.87 | LMNA (0.52) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL27797259 | 0.87 | LMNA (0.56) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Gluconic Acid SCHEMBL5142632 | 0.85 | PDE4A (0.76) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Demannose SCHEMBL870938 | 0.85 | LMNA (0.44) | LMNAL3MBTL1TDP1TP53PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4122443-B1 | COSMETIC COMPOSITION WITH SILICONE-MODIFIED POLYSACCHARIDE | SHINETSU CHEMICAL CO (JP) | 2026-05-06 | — | — | EP | disclosed |
| US-12539266-B2 | Cosmetic composition | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2026-02-03 | — | — | US | disclosed |
| EP-3699183-B1 | COSMETIC COMPRISING A UREA GROUP-CONTAINING ORGANOPOLYSILOXANE | SHINETSU CHEMICAL CO (JP) | 2024-07-24 | — | — | EP | disclosed |
| US-20230157942-A1 | COSMETIC | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2023-05-25 | — | — | US | disclosed |
| US-20230106469-A1 | COSMETIC COMPOSITION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2023-04-06 | — | — | US | disclosed |
| EP-4122443-A1 | COSMETIC COMPOSITION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2023-01-25 | — | — | EP | disclosed |
| EP-4112126-A1 | COSMETIC | Shin-Etsu Chemical Co., Ltd. (JP) | 2023-01-04 | — | — | EP | disclosed |
| EP-3527592-B1 | (METH)ACRYLIC SILICONE GRAFT COPOLYMER AND A METHOD FOR PREPARING THE SAME | SHINETSU CHEMICAL CO (JP) | 2021-05-05 | — | — | EP | disclosed |
| US-10851194-B2 | (meth)acrylic silicone graft copolymer and a method for preparing the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2020-12-01 | — | — | US | disclosed |
| EP-3699183-A1 | UREA GROUP-CONTAINING ORGANOPOLYSILOXANE, METHOD FOR PRODUCING UREA GROUP-CONTAINING ORGANOPOLYSILOXANE, AND COSMETIC PREPARATION | Shin-Etsu Chemical Co., Ltd. (JP) | 2020-08-26 | — | — | EP | disclosed |
| CN-100563623-C | Cosmetics | KANEBO COSMETICS INC SHINETSU (JP) | 2009-12-02 | — | — | CN | disclosed |
| US-7285290-B2 | Hydrophilized powder and a composition comprising the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2007-10-23 | — | — | US | disclosed |
| EP-1291377-B1 | SILICONE COMPOUND AND COSMETIC PREPARATION | SHINETSU CHEMICAL CO (JP) | 2007-03-28 | — | — | EP | disclosed |
| CN-1938000-A | Cosmetic containing siloxane polymer | SHINETSU CHEMICAL CO (JP) | 2007-03-28 | — | — | CN | disclosed |
| CN-1761449-A | Cosmetic preparation | KANEBO COSMETICS INC (JP) | 2006-04-19 | — | — | CN | disclosed |
| US-6984390-B2 | Silicone compound and cosmetic preparation | SHIN-ETSU CHEMICAL CO. LTD. (JP) | 2006-01-10 | — | — | US | disclosed |
| US-6784271-B2 | ADDITION REACTION BETWEEN A HYDROGEN SILOXANE AND A COMPOUND WITH A TERMINAL DOUBLE BOND IN THE PRESENCE OF A PLATINUM CATALYST | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2004-08-31 | — | — | US | disclosed |
| EP-1424373-A2 | Hydrophilized powder and a composition comprising the same | Shin-Etsu Chemical Company, Ltd. (JP) | 2004-06-02 | — | — | EP | disclosed |
| EP-1291376-A1 | SILICONE POLYMER, SILICONE COMPOSITION, AND COSMETIC PREPARATION CONTAINING THE SAME | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291377-A1 | SILICONE COMPOUND AND COSMETIC PREPARATION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2003-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230106469-A1 | COSMETIC COMPOSITION | CUTA, CD44, ALG1 | LMNA 2430/4885L3MBTL1 3804/4885TDP1 1133/4885 |
| US-12539266-B2 | Cosmetic composition | CUTA, FSCN1, FUCA1 | LMNA 1254/4885L3MBTL1 2351/4885TDP1 2044/4885 |
| US-10851194-B2 | (meth)acrylic silicone graft copolymer and a method for preparing the same | MSR1, ALG1, MTX2 | LMNA 2449/4885L3MBTL1 1239/4885TDP1 2550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.