Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sorbitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorbitol SCHEMBL628564 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Sorbitol SCHEMBL2165750 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL4424352 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL29732412 | 0.94 | LMNA (0.61) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Adonitol SCHEMBL27616531 | 0.89 | LMNA (0.53) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Sulfuric Acid SCHEMBL7156175 | 0.89 | LMNA (0.48) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL28118105 | 0.87 | LMNA (0.52) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Mannitol SCHEMBL27797259 | 0.87 | LMNA (0.56) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Gluconic Acid SCHEMBL5142632 | 0.85 | PDE4A (0.76) | LMNAL3MBTL1TDP1TP53PDE4A | |
| Demannose SCHEMBL870938 | 0.85 | LMNA (0.44) | LMNAL3MBTL1TDP1TP53PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59117547-A | — | — | None | — | — | JP | disclosed |
| EP-3492514-B1 | NOVEL SILICONE COMPOUND AND COSMETIC CONTAINING SAME | SHINETSU CHEMICAL CO (JP) | 2023-05-10 | — | — | EP | disclosed |
| US-11033481-B2 | Silicone resin, making method, and cosmetics | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2021-06-15 | — | — | US | disclosed |
| US-10787544-B2 | Silicone compound and cosmetic containing the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2020-09-29 | — | — | US | disclosed |
| US-10765619-B2 | Silicone resin, making method, and cosmetics | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2020-09-08 | — | — | US | disclosed |
| US-20200078289-A1 | SILICONE RESIN, MAKING METHOD, AND COSMETICS | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2020-03-12 | — | — | US | disclosed |
| US-20190211156-A1 | NOVEL SILICONE COMPOUND AND COSMETIC CONTAINING THE SAME | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2019-07-11 | — | — | US | disclosed |
| EP-2921518-B1 | ORGANOPOLYSILOXANE HAVING AMIDE GROUP, AND COSMETIC MATERIAL CONTAINING SAME | SHINETSU CHEMICAL CO (JP) | 2019-06-19 | — | — | EP | disclosed |
| EP-3492514-A1 | NOVEL SILICONE COMPOUND AND COSMETIC CONTAINING SAME | Shin-Etsu Chemical Co., Ltd. (JP) | 2019-06-05 | — | — | EP | disclosed |
| EP-2444062-B1 | Cosmetic product containing film-forming polymer | SHINETSU CHEMICAL CO (JP) | 2017-05-10 | — | — | EP | disclosed |
| EP-1496080-A1 | Alternating copolymer of organopolysiloxane with glycerol derivative and a cosmetic comprising the same | Shin-Etsu Chemical Company, Ltd. (JP) | 2005-01-12 | — | — | EP | disclosed |
| EP-1481660-A1 | Cosmetic | Shin-Etsu Chemical Co., Ltd. (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-6790451-B2 | SILICONE-BRANCHED SILICONE COMPOUND AND A SILICONE-BRANCHED POLYETHER-MODIFIED SILICONE AS COSMETIC INGREDIENTS; HIGH STABILITY IN AN EMULSIFIED STATE AND HIGH TRANSPARENCY; FEELING OF REFRESHMENT FOR THE USER | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2004-09-14 | — | — | US | disclosed |
| US-6576623-B1 | Compound or polymer containing siloxane and oxyalkylene groups; nonoily; spreads easily and smoothly; moist, fresh, dry feel; storage and heat stability | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| EP-1072627-B1 | Silicone compound and cosmetic materials containing the same | SHINETSU CHEMICAL CO (JP) | 2003-03-19 | — | — | EP | disclosed |
| EP-1213006-A1 | COSMETICS | KANEBO, LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |
| EP-1213316-A2 | Polyhydric alcohol-modified silicone and cosmetic material containing same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |
| EP-1213011-A1 | Cosmetic material comprising branched silicone compounds | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |
| EP-1072627-A2 | Silicone compound and cosmetic materials containing the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2001-01-31 | — | — | EP | disclosed |
| JP-S59117547-A | GELATINOUS COMPOSITION | SHISEIDO CO LTD | 1984-07-06 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190211156-A1 | NOVEL SILICONE COMPOUND AND COSMETIC CONTAINING THE SAME | CCND2, SRD5A1, DRD1 | LMNA 2471/4885L3MBTL1 2630/4885TDP1 1057/4885 |
| US-10787544-B2 | Silicone compound and cosmetic containing the same | FANCD2, CCND2, MRGPRX1 | LMNA 2418/4885L3MBTL1 2321/4885TDP1 1437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.