Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL4424352 | 0.93 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4ATP53 | |
| Sorbitol SCHEMBL5801966 | 0.90 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL27515859 | 0.90 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL28765531 | 0.89 | LMNA (0.55) | LMNAL3MBTL1TDP1PDE4ATP53 | |
| Sorbitol SCHEMBL628564 | 0.87 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4ATP53 | |
| Sorbitol SCHEMBL2165750 | 0.87 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4ATP53 | |
| Sorbitol SCHEMBL633334 | 0.87 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4ATP53 | |
| Mannitol SCHEMBL29732412 | 0.87 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4ATP53 | |
| Gluconic Acid SCHEMBL3446123 | 0.87 | LMNA (0.77) | LMNAL3MBTL1TDP1PDE4ATP53 | |
| Adonitol SCHEMBL27558452 | 0.85 | LMNA (0.58) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101049440-B | Preparation of Chinese traditional medicine in use for diabetes, and preparation method | BEIJING INCREASE BIOLOG PRODUCTS RES INST | 2010-11-10 | — | — | CN | disclosed |