Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.48 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.45 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | PI4KA | P42356 | 2/20 | 0.48 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.48 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.48 |
| ▸ | SLC28A1 | O00337 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.48 |
| ▸ | GAPDH | P04406 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL199259 | 0.99 | ADORA1 (0.51) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| Pyrophosphoric Acid SCHEMBL668584 | 0.94 | ADORA1 (0.52) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| SCHEMBL15665475 | 0.88 | ADORA1 (0.52) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| SCHEMBL8572697 | 0.87 | ADORA1 (0.38) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| SCHEMBL214972 | 0.87 | P2RY1 (0.59) | ADORA1SMN1; SMN2DNPH1PRKAB2TRPM2 | |
| SCHEMBL27971039 | 0.86 | FDPS (0.42) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| SCHEMBL13738525 | 0.86 | ADORA1 (0.38) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| Phosphoric Acid SCHEMBL23802568 | 0.85 | ADORA1 (0.50) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| Phosphoric Acid SCHEMBL15201527 | 0.85 | PI4KA (0.51) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| SCHEMBL668586 | 0.83 | P2RX1 (0.59) | ADORA1SMN1; SMN2DNPH1PRKAB2TRPM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118109378-A | Coli engineering bacterium for high-yield L-methionine and method for producing L-methionine by full fermentation method thereof | 浙江工业大学 | 2024-05-31 | — | — | CN | disclosed |
| CN-114846143-A | Expression of nitrogenase polypeptides in plant cells | 联邦科学技术研究组织 | 2022-08-02 | — | — | CN | disclosed |
| CN-114144527-A | Expression of nitrogenase polypeptides in plant cells | 联邦科学技术研究组织 | 2022-03-04 | — | — | CN | disclosed |
| US-8088897-B2 | Detecting the activity of and screening acceptor substrates, inhibitors, or activators of enzymes catalyzing group transfer reactions to facilitate the development of more selective and therapeutic drugs | BellBrook Labs, Inc. (US) | 2012-01-03 | — | — | US | disclosed |
| US-7847066-B2 | High throughput screening; immunoassays; immunogens; antibodies producing uridine diphosphate with higher affinity to carbohydrates | BELLBROOK LABS, LLC (US) | 2010-12-07 | — | — | US | disclosed |
| EP-2222708-A1 | ASSAY METHOD FOR GROUP TRANSFER REACTIONS | Bellbrook Labs, Llc (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090186358-A1 | Pathway Analysis of Cell Culture Phenotypes and Uses Thereof | WYETH (US) | 2009-07-23 | — | — | US | disclosed |
| WO-2009078876-A1 | ASSAY METHOD FOR GROUP TRANSFER REACTIONS | BELLBROOK LABS, LLC (US) | 2009-06-25 | — | — | WO | disclosed |
| US-20080255341-A2 | ASSAY METHOD FOR GROUP TRANSFER REACTIONS | LOWERY ROBERT | 2008-10-16 | — | — | US | disclosed |
| US-20080233592-A1 | Assay Method for Group Transfer Reactions | BELLBROOK LABS, LLC | 2008-09-25 | — | — | US | disclosed |
| US-20080188439-A1 | Directed metabolism of compounds by glucuronidation and sulfonation donors to decrease toxicity | SALHANICK STEVEN D | 2008-08-07 | — | — | US | disclosed |
| US-20080132684-A1 | Assay Method for Group Transfer Reactions | LOWERY ROBERT | 2008-06-05 | — | — | US | disclosed |
| US-7378505-B2 | Assay method for group transfer reactions | BELLBROOK LABS LLC (US) | 2008-05-27 | — | — | US | disclosed |
| US-7355010-B2 | Assay method for group transfer reactions | BELLBROOK LABS, LLC (US) | 2008-04-08 | — | — | US | disclosed |
| EP-1869083-A1 | ASSAY METHOD FOR GROUP TRANSFER REACTIONS | BellBrook Labs, LLC (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006127008-A1 | ASSAY METHOD FOR GROUP TRANSFER REACTIONS | BELLBROOK LABS, LLC (US) | 2006-11-30 | — | — | WO | disclosed |
| US-20060172335-A1 | Assay method for group transfer reactions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-08-03 | — | — | US | disclosed |
| US-20050239142-A1 | Assay method for group transfer reactions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-10-27 | — | — | US | disclosed |