SCHEMBL21660434

SCHEMBL21660434

CCc1ccc(OC)c(S(=O)(=O)N(C)c2noc3cc(CC)ccc23)c1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.43
▸ KAT7 O95251 6/20 0.43
▸ KAT6A Q92794 6/20 0.43
▸ KAT6B Q8WYB5 4/20 0.43
▸ KAT5 Q92993 2/20 0.43
▸ KAT8 Q9H7Z6 2/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ POLB P06746 1/20 0.42
▸ ALPL P05186 1/20 0.40
▸ TP53 P04637 1/20 0.38
▸ BRD4 O60885 1/20 0.38
▸ BRD2 P25440 1/20 0.38
▸ BRD3 Q15059 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24429774 0.82 KAT7 (0.39) MAPTKAT7KAT6AKAT6BKAT5
SCHEMBL24429772 0.82 KAT6A (0.39) MAPTKAT7KAT6AKAT6BKAT5
SCHEMBL29652370 0.80 KAT7 (0.41) MAPTKAT7KAT6AKAT6BKAT5
SCHEMBL21660565 0.80 KAT7 (0.57) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL21660335 0.78 BRD4 (0.40) MAPTKAT7KAT6AKAT6BKAT5
SCHEMBL21596819 0.76 KAT6A (0.66) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL21660533 0.76 POLB (0.41) MAPTKAT7KAT6AKAT6BKAT5
SCHEMBL28514884 0.76 BRD4 (0.38) MAPTKAT7KAT6AKAT6BMEN1
SCHEMBL29652474 0.76 BRD4 (0.38) MAPTKAT7KAT6AKAT6BMEN1
SCHEMBL29652373 0.75 TSHR (0.39) MAPTKAT7KAT6AKAT6BKAT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200039945-A1 Compounds SLC10A1, ABCB11, PCSK9 MAPT 1136/4885KAT7 490/4885KAT6A 878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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